Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long way from the final answer. A big next step is understanding how neuronal circuits connect to and guide bodily behavior. Very recent work on mapping the fruit-fly connectome has brought us closer to that goal. I talk with neuroscientist Bing Brunton about the connectome, how we can study it to understand bodily motion in flies and other creatures, and where it's all taking us.
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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/27/352-bing-brunton-on-connecting-the-connectome-to-the-body/
Bing Wen Brunton received her Ph.D. in neuroscience from Princeton University.. She is currently a Professor of Biology and the Richard & Joan Komen University Chair at the University of Washington, with affiliations at the eScience Institute for Data Science, the Paul G. Allen School of Computer Science & Engineering, and the Department of Applied Mathematics.
Web site
University of Washington web page
Google Scholar publications
YouTube channel
Bluesky
Artworks (Instagram)

Peter Singer has been an influential philosopher for a number of decades. He was a significant early voice in animal rights, has been a leading thinker of utilitarianism, and helped inspire the effective altruism movement. In this podcast episode, we try our best to talk about all of those things -- working from metaethical questions of consequentialism vs. other approaches, to specific flavors of utilitarianism, the practical demands that ethics places on people, the rights of animals, and the decisions we make at the end of our lives.





Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/20/351-peter-singer-on-maximizing-good-for-all-sentient-creatures/







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Peter Singer received his B.Phil. in philosophy from the University of Oxford. He retired from Princeton University in 2023, and now lives in Melbourne, Australia. He is the author of a number of influential books, including Animal Liberation (1975). He has been named a Companion of the order of Australia, and is a winner of the Berggruen Prize. He is the founder of the charity The Life You Can Save. He and philosopher Kasia de Lazari Radek are co-hosts of the Lives Well Lived podcast (YouTube, Spotify, Apple).
Web site
Princeton University Center for Human Values page
Google Scholar publications
Amazon author page
Wikipedia
Bluesky

We are more familiar with ourselves than with anything else in the universe, but we generally don't come very close to really understanding what our "self" is. That's not too surprising, as selves are very complicated and we are burdened by all sorts of biases. Today's guest is J. Eric Oliver, who has been teaching a popular course at the University of Chicago called "The Intelligible Self." His academic specialty is political science, but he brings together ideas from psychology, neuroscience, and a broad swath of the humanities. His view is summarized in his recent book, How to Know Yourself: The Art and Science of Discovering Who You Really Are.
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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/13/350-j-eric-oliver-on-the-self-and-how-to-know-it/







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J. Eric Oliver received his Ph.D. in political science from the University of California, Berkeley. He is currently a Professor of Political Science at the University of Chicago. His research interests include contemporary American politics, suburban and racial politics, political psychology, and the politics of science. He is the host of the podcast Knowing: With Eric Oliver.
Web site
U Chicago web page
Google Scholar publications
Amazon author page

Welcome to the April 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy!
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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/06/ama-april-2026/






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There is something special about gravity. After decades of effort, there is still no convergence on the right way to reconcile Einstein's theory of general relativity with the framework of quantum mechanics. But a number of intriguing ideas have arisen along the way, including black hole radiation, the wave function of the universe, the AdS/CFT correspondence, and the role of quantum information theory. Theoretical physicist Daniel Harlow has made significant contributions to our understanding of information loss in black holes; in this conversation we turn those insights onto quantum cosmology, with potentially significant implications for how quantum mechanics itself works.





Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/03/30/349-daniel-harlow-on-what-quantum-gravity-teaches-us-about-quantum-mechanics/
 
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Daniel Harlow received his Ph.D. in physics from Stanford University. He is currently an associate professor of physics at the Massachusetts Institute of Technology. Among his awards are a Packard Fellowship and the New Horizons in Physics Prize.
Web site
MIT web page
Google Scholar publications
Wikipedia