The Karl Stefanovic Show

What if scientists could actually turn back the biological clock?
On this episode of In Conversation, Karl Stefanovic sits down with Dr Buck Parker, MD, FACS – a board-certified trauma and acute care surgeon and digital creator – to unpack one of the most extraordinary developments in modern medicine: the possibility of reprogramming ageing cells.
Dr Parker explains how scientists have discovered that cells are programmable, how four key proteins can reset the epigenetic ‘clock’ inside cells, and why researchers are now testing whether older cells can effectively be made younger.
Human trials are already underway, while experiments in mice have produced striking results – but Dr Parker explains why there are still major questions around dosage, delivery, cancer risk and the long-term effects.
Karl and Buck also dive into the explosion of peptides and wellness treatments, the growing influence of social media on medicine, patients using ‘Dr Google’ and ‘Dr AI’, and why he believes medicine is entering a completely new era.
So would Buck take the so-called fountain of youth himself? And how long could we have to wait before humans can actually slow or stop ageing?
His prediction: five to ten years.
Plus, Buck reveals what he actually takes, why he uses creatine, his experience with NAD and GLPs, and the simple things he recommends doing now to stay healthy.
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Labor is under fire – and Hollie Hughes and Gerard Rennick aren't holding back.
This week on The Panel, Karl Stefanovic is joined by former Liberal MP Hollie Hughes and Gerard Rennick for a fiery discussion about the Albanese Government, Jim Chalmers, the gun buyback, superannuation, energy and the growing political divide.
Hollie Hughes takes aim at Treasurer Jim Chalmers over his fundraising appeal, questioning why Australians struggling with the cost of living would be sending money to Labor.
The panel also tackles the Government’s gun buyback scheme, with Hughes arguing farmers are being punished for the actions of criminals and questioning the Government’s response to the Bondi terror attack.
Gerard Rennick takes aim at Australia’s superannuation system, arguing it is making it harder for younger and lower-income Australians to get into the housing market, while warning that the cost of superannuation tax concessions is already enormous.
Plus, the panel gets into Chris Bowen, Australia’s energy future, struggling infrastructure and the controversial Robert Irwin moment at the Logies – with Hollie Hughes delivering a particularly fiery response.
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Tonight on Karl Weekly, Dave Hughes explains why he’s hit the campaign trail with the Victorian Liberals – and why he says he’s had enough of Labor’s taxes, government waste and corruption.
Hughesy reveals what pushed him to become more politically outspoken, why he believes Australians are ‘over it’, and why he thinks Victoria desperately needs a change of government. He also takes aim at the Commonwealth Games blowout, government spending and the lack of accountability for decisions that have left Victoria billions in debt.
Karl also speaks to sixth-generation Victorian farmer Ben Duxson, who is fighting $814 fines issued to farmers for refusing access to their own properties as the government pushes ahead with the $11.4 billion VNI West transmission project, with Pauline Hanson joining the farmers’ campaign.
And former AFP Detective Superintendent Dr David Craig joins Karl to examine the government’s new gun buyback following the Bondi terror attack. Craig questions whether taking legal firearms off law-abiding Australians will actually make the country safer, and warns that the legislation will not stop the next terrorist attack.
He also reveals where he believes the real security failures occurred – from counterterrorism funding and intelligence sharing to the resources available to ASIO and the AFP – and warns that another Bondi attack could happen if those gaps aren't addressed.
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Dr Aseem Malhotra joins Karl for a wide-ranging conversation about vaccines, COVID, Big Pharma, medical research and the growing crisis of trust in the health system.
Malhotra discusses Donald Trump and RFK Jr’s approach to childhood vaccinations, why he believes every medical intervention should come with genuine informed consent, and why he says doctors need to be more transparent about the risks, benefits and uncertainties surrounding treatment.
He also takes aim at the pharmaceutical industry, questions the independence of medical regulators, and delivers a provocative challenge to conventional thinking around cholesterol and statins.
Malhotra reflects on the mistakes made during COVID, arguing that governments and medical authorities need to admit where they got things wrong if public trust is ever going to be restored.
He also weighs in on Anthony Fauci, the polarisation of left and right, the psychology behind the pandemic response, social media’s role in fuelling anger, and why he believes Australians and Britons need to find a way to debate without becoming trapped in opposing camps.
Plus, Malhotra explains why he changed his own position on COVID vaccines and why he believes changing your mind can be one of the hardest – but most important – things a person can do.
Subscribe to The Karl Stefanovic Show for more interviews, debate and conversations on the biggest issues facing Australia, the UK and the world.

The Fabian Society has influenced political thinking for more than 140 years – but how much influence does it really have over Australia?
Karl speaks with Topher Field about the origins of Fabianism, its strategy of gradual political change and the controversial idea of ‘permeation’, influencing institutions and government from within rather than seeking power directly.
Topher argues the Fabian approach has become deeply embedded in modern politics, warning that ‘if you accept that framework as the way that government should function, the Fabians have already won.’ He also reveals why he believes Fabian influence extends beyond Labor and into the Liberal Party.
They discuss the growth of bureaucracy, regulation and expert-led government – and why Topher believes ‘they’ve already got you without you even having to know their name.’
This is The Karl Stefanovic Show.