The Feldman Protocol

In this episode of The Feldman Protocol, how well do conventional cardiovascular risk metrics actually identify who is truly at risk for a heart attack decades before it happens? Cardiologist Arthur Agatston (MD) makes the case for coronary calcium scoring as an early detection tool, discusses the natural history of atherosclerotic plaque, revisits key moments in lipid science history, explores why stent placement in asymptomatic patients presents a more complex picture than intuition suggests, and shares observations on the evolving role of CT angiography and AI-assisted plaque analysis.

🔥 This episode is sponsored by us --
Own Your Labs 👉 `https://ownyourlabs.com/sp/50`
Private blood testing services
🩸Over 300 blood tests
💰Extremely affordable
❤️ We love our customers
(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:
Main Channel: `https://youtube.com/@realDaveFeldman`
X/Twitter: `https://x.com/realDaveFeldman`
Instagram: `https://instagram.com/realDaveFeldman`
Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & introduction
7:46 – Arthur's path into medicine
18:59 – Early cardiology & clinical trials
27:47 – Lipid science history & Ancel Keys
39:04 – Rabbit studies & lipoprotein discovery
47:15 – Ultra-fast CT arrives at Sinai
55:26 – Collateral vessels & total occlusion
1:00:00 – Ischemia trial: stents vs. medical therapy
1:05:01 – Back to the CAC origin story
1:13:09 – Soft vs. calcified plaque progression
1:21:40 – FH patient with zero CAC score
1:26:53 – The Agatston score is named
1:33:51 – Power of zero & plaque burden
1:39:35 – CAC vs. CT angiogram explained
1:44:19 – Resistance to new imaging technology
1:48:34 – Nutrition interest in the 1990s
1:49:25 – Heart Lung AI & plaque ratio research
1:51:11 – Closing reflections

#FeldmanProtocol #DaveFeldman #ArthurAgatston #CoronaryCalcium #HeartHealth #Atherosclerosis #CardiacImaging #CACScore #LDL #Lipids #PlaqueBiology #CTAngiogram #CardiologyResearch #LowCarbDiet #LeanMassHyperResponder #HeartDiseasePrevention #LipidScience #CardiovascularResearch

In this episode of The Feldman Protocol, how does insulin influence cancer cell behavior — and what does that mean for metabolic approaches to the disease? Dave sits down with Isabella Cooper (PhD) to explore the glucose-ketone index and its practical limits, the role of glutamine alongside glucose in cancer metabolism, how mitochondrial dysfunction and cardiolipin loss may relate to tumor progression, the case for high-dose intravenous vitamin C, osteocyte biology and the surprising systemic roles of osteocalcin, and what makes a rigorous research culture.

🔥 This episode is sponsored by us --
Own Your Labs 👉 `https://ownyourlabs.com/sp/49`
Private blood testing services
🩸Over 300 blood tests
💰Extremely affordable
❤️ We love our customers
(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:
Main Channel: `https://youtube.com/@realDaveFeldman`
X/Twitter: `https://x.com/realDaveFeldman`
Instagram: `https://instagram.com/realDaveFeldman`
Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & intro
1:08 – Cancer metabolism overview
2:24 – Glucose-ketone index explained
5:01 – Lean mass hypersponders & glucose
9:18 – Acetone measurement & respiration
13:49 – Insulin, ketones & cancer signaling
19:05 – Growth factors & VEGF discussion
25:29 – Stomach acidity & nutrient absorption
32:08 – How cancer cells originate
35:43 – Cardiolipin, melatonin & apoptosis
43:05 – Diet quality & food as function
52:14 – Chemotherapy & metabolic protocols
1:03:36 – Patient outcomes & biopsy risks
1:14:32 – IV vitamin C trial findings
1:22:07 – Ideal cancer metabolism trial design
1:29:36 – Sunlight, melanin & mitochondria
1:37:20 – Osteocyte biology & osteocalcin
1:46:43 – Research culture & scientific rigor
1:54:36 – Most underappreciated biomarker

#FeldmanProtocol #DaveFeldman #IsabellaCooper #CancerMetabolism #KetogenicDiet #Mitochondria #Insulin #GlucoseKetoneIndex #Osteocalcin #IntravenousVitaminC #Ketosis #MetabolicHealth #LowCarbScience #CancerResearch #Cardiolipin #Osteocytes #BloodWork #Hyperinsulinemia #MitochondrialHealth #PodcastScience

In this episode of The Feldman Protocol, what does beta-hydroxybutyrate between meals actually reveal about a person's insulin state — and why might that matter for understanding chronic disease risk? Dave sits down with Isabella Cooper (PhD), a biochemistry and pathophysiology scientist whose research spans assay quality control, hyperinsulinemia detection, ketone thresholds, mitochondrial function, and the lipid energy model, making the case that personalized insulin thresholds — not population-wide cutoffs — may be key to identifying subclinical metabolic dysfunction.🔥 This episode is sponsored by us --Own Your Labs 👉 `https://ownyourlabs.com/sp/48` Private blood testing services🩸Over 300 blood tests💰Extremely affordable❤️ We love our customers(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)🔗 CONNECT WITH DAVE FELDMAN:Main Channel: `https://youtube.com/@realDaveFeldman`X/Twitter: `https://x.com/realDaveFeldman`Instagram: `https://instagram.com/realDaveFeldman`Website: `https://thefeldmanprotocol.com`⏱ Chapters0:00 – Cold open & intro1:06 – Isabella's background & credentials3:05 – East-meets-West medicine upbringing5:43 – Ballet, modeling & low-carb insights6:36 – Industrial design degree & lab thinking8:58 – Assay quality problems in undergrad lab12:08 – Coefficient of variation explained17:01 – Standardizing vortex & sample handling27:30 – Back to timeline: the 15-year gap39:52 – Pregnancy, diapers & toxicology deep dive53:06 – Old physiology papers vs modern science1:00:05 – Osteocalcin hypothesis & being wrong1:06:48 – Ben Bikman, mitochondria & insulin1:19:40 – Headwinds for low-carb research1:34:19 – Personalized insulin threshold concept1:41:28 – Beta-hydroxybutyrate as insulin surrogate1:51:44 – Leptin, IGF-1 & multi-marker detection2:09:09 – Subclinical hyperinsulinemia marker cluster2:14:20 – Fasting, lipid dynamics & VLDL traffic#FeldmanProtocol #DaveFeldman #IsabellaCooper #Hyperinsulinemia #Ketosis #Mitochondria #MetabolicHealth #InsulinResistance #BetaHydroxybutyrate #LowCarb #ChronicDisease #LipidEnergyModel #AssayQuality #KetoneThreshold #LaboratoryScience #Bioenergetics #BloodTesting #Inflammation

In this episode of The Feldman Protocol, how much does metabolic health shape cardiovascular risk beyond what standard lipid markers can reveal? Dave Feldman sits down with Scott Murray (MD), a UK-based interventional cardiologist, to explore plaque imaging and its limitations, the role of visceral and perivascular fat in heart disease, the lipid energy model and lean mass hyper-responders, cardiac fuel metabolism and heart failure with preserved ejection fraction, and the challenges of conducting and interpreting cardiovascular trials.

🔥 This episode is sponsored by us --
Own Your Labs 👉 `https://ownyourlabs.com/sp/47`
Private blood testing services
🩸Over 300 blood tests
💰Extremely affordable
❤️ We love our customers
(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:
Main Channel: `https://youtube.com/@realDaveFeldman`
X/Twitter: `https://x.com/realDaveFeldman`
Instagram: `https://instagram.com/realDaveFeldman`
Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & Scott's intro
14:21 – Scott's cardiology practice
17:28 – Invasive vs. CT angiography
24:49 – Collaterals & microvascular function
34:31 – Glycocalyx & endothelial health
40:28 – Perivascular fat & imaging
51:14 – Imaging, CAC, and plaque noise
1:00:04 – Lipid hypothesis & population context
1:07:05 – CT plaque measurement variability
1:19:42 – Perivascular inflammation & Caristo scoring
1:29:07 – Lipid energy model discussion
1:49:43 – LP(a), acute-phase markers & reverse causation
2:05:01 – LMHR study timeline & next scans
2:22:57 – Heart fuel preference & HFpEF
2:39:08 – PCSK9 trials & all-cause mortality
2:52:06 – Run-in periods & trial design concerns
3:05:00 – Context, guidelines & patient conversations
3:17:35 – GLP-1 peptides & obesity biology
3:26:28 – Where to find Scott & closing thoughts

#FeldmanProtocol #DaveFeldman #ScottMurray #PreventiveCardiology #HeartHealth #LipidHypothesis #LeanMassHyperResponder #CTAngiography #PlaqueImaging #CardiovascularResearch #MetabolicHealth #LipidEnergyModel #HeartFailure #LPa #GLP1 #TrialDesign #Cardiology #LowCarb #BloodWork

In this episode of The Feldman Protocol, what actually drives cardiovascular disease in a metabolically healthy, lean individual — and is elevated LDL the most important variable to consider? Darius Sharpe (ER nurse and lean mass hypersponder community member) discusses his unexpected CAC score at age 38, his theory on postprandial glucose and vascular damage, a personal episode of atrial fibrillation, the Keto CTA study's Clearly data controversy, and what ER nurses observe firsthand about metabolic illness.

🔥 This episode is sponsored by us --
Own Your Labs 👉 `https://ownyourlabs.com/sp/43`
Private blood testing services
🩸Over 300 blood tests
💰Extremely affordable
❤️ We love our customers
(Yes, we are literally funding the entire podcast from our own company -- so if you want to show your support, keep getting your private blood testing through our service. Thank you! 🙏)

🔗 CONNECT WITH DAVE FELDMAN:
Main Channel: `https://youtube.com/@realDaveFeldman`
X/Twitter: `https://x.com/realDaveFeldman`
Instagram: `https://instagram.com/realDaveFeldman`
Website: `https://thefeldmanprotocol.com`

⏱ Chapters

0:00 – Cold open & CAC score reveal
4:51 – Darius's CAC scan background
9:07 – First-phase insulin response explained
15:47 – CAC result context & vessel findings
22:09 – Darius investigates his own cardiac risk
33:43 – Atrial fibrillation episode & AFIB physiology
43:28 – Electrolytes, magnesium, and sodium discussion
51:04 – Stress tests vs. imaging: a patient case
58:01 – Metabolic syndrome underdiagnosis in hospitals
1:03:09 – Dave's diet experiments & LMHR data
1:09:18 – Fat bomb experiment: NMR findings
1:20:53 – Lipid energy model & structural hypothesis
1:30:37 – Keto CTA: plaque associations & progressors
1:39:41 – Clearly data controversy & scientific transparency
1:51:55 – Glucose, hyperglycemia, and plaque theory
2:05:22 – Raw data release & cards on the table
2:15:01 – ER realities & medication safety
2:29:07 – Lifestyle, habits, and the ER patient perspective
2:39:10 – Where to find Darius & closing thoughts

#FeldmanProtocol #DaveFeldman #DariusSharpe #LeanMassHypersponder #KetoCTA #CACScore #AtrialFibrillation #PostprandialGlucose #MetabolicSyndrome #LipidEnergyModel #CardiovascularHealth #CGM #LDL #InsulinResponse #ERNurse #BloodTesting #HeartHealth #NMRPanel