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  • Edge AI Foundation's Pete Bernard on an Edge-First Framework: Eliminate Cloud Tax Running AI On Site
    Pete Bernard, CEO of Edge AI Foundation, breaks down why enterprises should default to running AI at the edge rather than the cloud, citing real deployments where QSR systems count parking lot cars to auto-trigger french fry production and medical implants that autonomously adjust deep brain stimulation for Parkinson's patients. He shares contrarian views on IoT's past failures and how they shaped today's cloud-native approach to managing edge devices. Topics discussed: Edge-first architectural decision framework: Run AI where data is created to eliminate cloud costs (ingress, egress, connectivity, latency) Market growth projections reaching $80 billion annually by 2030 for edge AI deployments across industries Hardware constraints driving deployment decisions: fanless systems for dusty environments, intrinsically safe devices for hazardous locations Self-tuning deep brain stimulation implants measuring electrical signals and adjusting treatment autonomously, powered for decades without external intervention Why Bernard considers Amazon Alexa "the single worst thing to ever happen to IoT" for creating widespread skepticism Solar-powered edge cameras reducing pedestrian fatalities in San Jose and Colorado without infrastructure teardown Generative AI interpreting sensor fusion data, enabling natural language queries of hospital telemetry and industrial equipment health
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  • PATH's Bilal Mateen on the measurement problem stalling healthcare AI
    PATH's Chief AI Officer Bilal Mateen reveals how a computer vision tool that digitizes lab documents cut processing time from 90 days to 1 day in Kenya, yet vendors keep pitching clinical decision support systems instead of these operational solutions that actually move the needle. After 30 years between FDA approval of breast cancer AI diagnostics and the first randomized control trial proving patient benefit, Mateen argues we've been measuring the wrong things: diagnostic accuracy instead of downstream health outcomes. His team's Kenya pilot with Penda Health demonstrated cash-releasing ROI through an LLM co-pilot that prevented inappropriate prescriptions, saving patients and insurers $50,000 in unnecessary antibiotics and steroids. What looks like lost revenue to the clinic represents system-wide healthcare savings. Topics discussed: The 90-day to 1-day document digitization transformation in Kenya Research showing only 1 in 20 improved diagnostic tests benefit patients Cash-releasing versus non-cash-releasing efficiency gains framework The 30-year gap between FDA approval and proven patient outcomes Why digital infrastructure investment beats diagnostic AI development Hidden costs of scaling pilots across entire health systems How inappropriate prescription prevention creates system-wide savings Why operational AI beats clinical decision support in resource-constrained settings
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  • Dr. Lisa Palmer on "Resistance-to-ROI": Why business metrics break through organizational fear
    Dr. Lisa Palmer brings a rare "jungle gym" career perspective to enterprise AI, having worked as a CIO, negotiated from inside Microsoft and Teradata, led Gartner's executive programs, and completed her doctorate in applied AI just six months after ChatGPT hit the market. In this conversation, she challenges the assumption that heavily resourced enterprises are best positioned for AI success and reveals why the MIT study showing 95% of AI projects fail to impact P&L, and what successful organizations do differently. Key Topics Discussed: Why Heavily Resourced Organizations Are Actually Disadvantaged in AI Large enterprises lack nimbleness; power companies now partner with 12+ startups. Two $500M-$1B companies are removing major SaaS providers using AI replacements. The "Show AI Don't Tell It" Framework for Overcoming Resistance Built interactive LLM-powered hologram for stadium executives instead of presentations. Addresses seven resistance layers from board skepticism to frontline job fears. Got immediate funding. Breaking "Pilot Purgatory" Through Organizational Redesign Pilots create "false reality" with cross-functional collaboration absent in siloed organizations. Solution: replicate pilot's collaborative structure organizationally, not just deploy technology. The Four Stage AI Performance Flywheel Foundation (data readiness, break silos), Execution (visual dartboarding for co-ownership), Scale (redesign processes), Innovation (AI surfaces new use cases). Why You Need a Business Strategy Fueled by AI, Not an AI Strategy MIT shows 95% failure from lacking business focus. Start with metrics (competitive advantage, cost reduction) not technology. Stakeholders confuse AI types. The Coming Shift: Agentic Layers Replacing SaaS GUIs Organizations building agent layers above SaaS platforms. Vendors opening APIs survive; those protecting walled gardens lose decades-old accounts. Building Courageous Leadership for AI Transformation "Bold AI Leadership" framework: complete work redesign requiring personal career risk. Launching certifications. Insurance company reduced complaints 26% through human-AI process rebuild.
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  • Virtuous’ Nathan Chappell on the CAIO shift: From technical oversight to organizational conscience
    Nathan Chappell's first ML model in 2017 outperformed his organization's previous fundraising techniques by 5x—but that was just the beginning. As Virtuous's first Chief AI Officer, he's pioneering what he calls "responsible and beneficial" AI deployment, going beyond standard governance frameworks to address long-term mission alignment. His radical thesis: the CAIO role has evolved from technical oversight to serving as the organizational conscience in an era where AI touches every business process. Topics Discussed: The Conscience Function of CAIO Role: Nathan positions the CAIO as "the conscience of the organization" rather than technical oversight, given that "AI is among in and through everything within the organization"—a fundamental redefinition as AI becomes ubiquitous across all business processes "Responsible and Beneficial" AI Framework: Moving beyond standard responsible AI to include beneficial impact—where responsible covers privacy and ethics, but beneficial requires examining long-term consequences, particularly critical for organizations operating in the "currency of trust" Hiring Philosophy Shift: Moving from "subject matter experts that had like 15 years domain experience" to "scrappy curious generalists who know how to connect dots"—a complete reversal of traditional expertise-based hiring for the AI era The November 30, 2022 Best Practice Reset: Nathan's framework that "if you have a best practice that predates November 30th, 2022, then it's an outdated practice"—using ChatGPT's launch as the inflection point for rethinking organizational processes Strategic AI Deployment Pattern: Organizations succeeding through narrow, specific, and intentional AI implementation versus those failing with broad "we just need to use AI" approaches—includes practical frameworks for identifying appropriate AI applications Solving Aristotle's 2,300-Year Philanthropic Problem: Using machine learning to quantify connection and solve what Aristotle identified as the core challenge of philanthropy—determining "who to give it to, when, and what purpose, and what way" Failure Days as Organizational Learning Architecture: Monthly sessions where teams present failed experiments to incentivize risk-taking and cross-pollination—operational framework for building curiosity culture in traditionally risk-averse nonprofit environments Information Doubling Acceleration Impact: Connecting Eglantine Jeb's 1927 observation that "the world is not unimaginative or ungenerous, it's just very busy" to today's 12-hour information doubling cycle, with AI potentially reducing this to hours by 2027
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  • Zayo Group's David Sedlock on Building Gold Data Sets Before Chasing AI Hype
    What happens when a Chief Data & AI Officer tells the board "I'm not going to talk about AI" on day two of the job? At Zayo Group, the largest independent connectivity company in the United States with around 145,000 route miles, it sparked a systematic approach that generated tens of millions in value while building enterprise AI foundations that actually scale. David Sedlock inherited a company with zero data strategy and a single monolithic application running the entire business. His counterintuitive move: explicitly refuse AI initiatives until data governance matured. The payoff came fast—his organization flipped from cost center to profit center within two months, delivering tens of millions in year one savings while constructing the platform architecture needed for production AI. The breakthrough insight: encoding all business logic in portable Python libraries rather than embedding it in vendor tools. This architectural decision lets Zayo pivot between AI platforms, agentic frameworks, and future technologies without rebuilding core intelligence, a critical advantage as the AI landscape evolves. Topics Discussed: Implementing "AI Quick Strikes" methodology with controlled technical debt to prove ROI during platform construction - Sedlock ran a small team of three to four people focused on churn, revenue recognition, and service delivery while building foundational capabilities, accepting suboptimal data usage to generate tens of millions in savings within the first year. Architecting business logic portability through Python libraries to eliminate vendor lock-in - All business rules and logic are encoded in Python libraries rather than embedded in ETL tools, BI tools, or source systems, enabling seamless migration between AI vendors, agentic architectures, and future platforms without losing institutional intelligence. Engineering 1,149 critical data elements into 176 business-ready "gold data sets" - Rather than attempting to govern millions of data elements, Zayo identified and perfected only the most critical ones used to run the business, combining them with business logic and rules to create reliable inputs for AI applications. Achieving 83% confidence level for service delivery SLA predictions using text mining and machine learning - Combining structured data with crawling of open text fields, the model predicts at contract signing whether committed timeframes will be met, enabling proactive action on service delivery challenges ranked by confidence level. Democratizing data access through citizen data scientists while maintaining governance on certified data sets - Business users gain direct access to gold data sets through the data platform, enabling front-line innovation on clean, verified data while technical teams focus on deep, complex, cross-organizational opportunities. Compressing business requirements gathering from months to hours using generative AI frameworks - Recording business stakeholder conversations and processing them through agentic frameworks generates business cases, user stories, and test scripts in real-time, condensing traditional PI planning cycles that typically involve hundreds of people over months. Scaling from idea to 500 users in 48 hours through data platform readiness - Network inventory management evolved from Excel spreadsheet to live dashboard updated every 10 minutes, demonstrating how proper foundational architecture enables rapid application development when business needs arise. Reframing AI workforce impact as capability multiplication rather than job replacement - Strategic approach of hiring 30-50 people to perform like 300-500 people, with humans expanding roles as agent managers while maintaining accountability for agent outcomes and providing business context feedback loops. Listen to more episodes:  Apple  Spotify  YouTube
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The Chief AI Officer Show bridges the gap between enterprise buyers and AI innovators. Through candid conversations with leading Chief AI Officers and startup founders, we unpack the real stories behind AI deployment and sales. Get practical insights from those pioneering AI adoption and building tomorrow’s breakthrough solutions.
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