The James Cancer-Free World Podcast

• Episode 201: How a clinical trial could change leukemia treatment

  Karilyn Larkin, MD, is leading a new clinical trial that could change and improve the way acute myelogenous leukemia (AML) is treated. “AML is a good example of how the better you understand the disease and the more clever you are in designing the clinical trial allows you to start to see successes where there were none before,” said Larkin, a James physician and hematologist. “In the past 10 years there have been more than 10 new drugs approved for treating AML which is phenomenal.”

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• Episode 200: Advances in Understanding & Treating Lung Cancer, with Triparna Sen, PhD

  “We have made great progress in treating lung cancer, but we still have a long way to go,” said Triparna Sen, PhD, a James scientist who specializes in translational research to better understand and treat lung cancer. Listen as Sen explains the biology and differences between the two different types of lung cancer (non-small cell and the less common, but more aggressive small cell); the latest treatments, including immunotherapy; and how a better understanding of the biology of cancer cells has led to improved drugs (such as immunotherapy) and better outcomes for patients. She also described how cancer cells are able to adapt and transform their biology and actually become “a new form of cancer.” Once this happens, over the course of several months, the immunotherapy drugs “no longer recognize the tumor.”

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• Episode 199: How fasting can affect cancer treatment, with Faiza Kalam, PhD, MD

  Fasting and intermittent fasting have been in the news in recent months. In this episode, Faiza Kalam, PhD, MD, director of the James Food, Activity Sleep and Time (FACT) Lab explains the basics and how fasting and intermittent fasting can lead to improved cholesterol, LDL and blood pressure levels and rates and help people lose weight without the use of weight-reducing drugs that can have side effects. Fasting can also help cancer patients during their treatment. “The initial research has shown there is less fatigue and better quality of life for cancer patients during chemotherapy treatment who fast,” said Kalam.

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• Episode 198: What you need to know about lobular breast cancer, with Arya Roy, MD

  While researchers work to improve lobular breast cancer screening, innovative treatments are improving outcomes for patients with a condition diagnosed in more than 40,000 Americans each year. Ohio State medical oncologist Arya Roy, MD, shares details about lobular breast cancer, also called invasive lobular carcinoma (ILC), including risks, symptoms and treatments.

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• Episode 197: How the James Lifestyle Lab Improves the Lives of Cancer Patients, with Roberto Benzo

  “We develop, evaluate and test interventions to help empower people to live healthier,” explained Roberto Benzo, PhD, an Ohio State health promotion and behavioral scientist and director of the James Lifestyle Lab. “We focus on empowering people to eat and exercise better and better manage their stress … helping people find the right solutions at the right time.” In this episode, Benzo explained how exercise, diet and managing stress are important for everyone, and for cancer patients during and after their treatment. “Even after a cancer diagnosis it’s not too late [to change behaviors],” Benzo said. “Being active and eating well can help you better tolerate your treatment and better manage your symptoms.” One of the tools Benzo and his team use re mobile health technologies such as iPhones, Fitbits and Apple Watches, as well as more accurate “research-grade” mobile technology applications. “The data helps us better understand where people are at,” he said. “And helps us establish new goals and behaviors.” Benzo said it can be hard to change long-held lifestyle routines and he offered some tips … “Consistency is one of the top secrets. You don’t have to do a super-hard work out every day, consistency means doing something every day.” “Acceptance and awareness of where you are is important, being at peace with where you are and not trying to push too hard to get to where you want to be.” Goal setting … “but setting compassionate goals within your means.” Social support … “having someone to help you, for emotional support, for informational support and someone to help you do things, such as exercising, and it may not be the same person for all three.” Benzo’s overall goal is “to help people find acceptance, compassion [for themselves], patience and resilience and use this to help them and motivate them and feel less along, and find joy and contentment for what they do already have.” Follow The James Cancer-Free World Podcast: · YouTube: go.osu.edu/C27H · Spotify: go.osu.edu/C8pY · Apple Podcasts: go.osu.edu/C2n6 Subscribe to The James on YouTube: www.youtube.com/@UCXGasnfbCpWYVW2RLTDPn4Q Learn more about cancer care and research at The Ohio State University: Home: cancer.osu.edu Blog: cancer.osu.edu/blog News: cancer.osu.edu/news

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