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Wet market SARS CoV-2 origins revisited
Last week, the website covid.gov looked very different, containing information on coping with covid and US research. This week it leads you to a White House webpage outlining the lab-leak hypothesis – that the pandemic was the result of dodgy lab work at the Wuhan Institute of Virology. The scientific consensus however continues to suggest a zoonotic crossover event. And a preprint recently published by Zach Hensel of ITQB NOVA (NOVA University Lisbon) and Florence Débarre of the Sorbonne, adds new early sequences to the evidence base. As they suggest, it doesn’t seal the debate, but it certainly doesn’t surprise the scientists.As the Trump administration continues to rattle swords with US science, we speak with Lisa Fazio of Vanderbuilt University who found out abruptly her funding from the National Science Foundation is ending, and Don Ingber, founding director of Harvard University’s Wyss Institute about the impacts they are feeling from the federal belt tightening.Finally we learn this week of an eerie species of Hawai’ian caterpillar moth. Not only is it carnivorous, but it ties small pieces of the indigestible remains of insects and bugs found in spider webs to its case, like a gruesome, camouflaged suit of armour. Why? As Dan Rubinoff of Hawai’i describes, it protects it from the hungry host spider, making it appear as the leftovers of yesterday’s dinner, or perhaps the shed exoskeleton of the spider itself.Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Josie Hardy(Image: The view of Huanan seafood market on February 9, 2021 in Wuhan, Hubei Province, China. Credit: Getty Images)
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35:17
Any more for Moore’s Law?
After 60 years of doubling computer complexity every two years, can Moore’s law still predict the future power of the devices we use?In 1965, electronics pioneer Gordon Moore was asked to predict the next ten years of progress with the then new-fangled silicon integrated circuits. He estimated, based on physics and manufacturing technologies then available what seemed remarkable: that every two years they would double in complexity, and halve in price, until 1975.60 years on, perhaps the even more remarkable thing is that they just kept doubling.Can Moore’s law hold into future decades? What are the next technological innovations that might keep it running? Sri Samavedam is the vice president for silicon technologies at imec in Belgium, whose job it is to think about the practicalities of manufacturing the next generations of chips years before they become real.Scott Aaronsen of the University of Texas is a thinker in the field of Quantum Computing – could quantum computing keep the rate of growth going? Or does it need to be thought of differently?One of the limitations on chip miniaturisation is the dissipation of heat from conventional electronic flow. Nick Harris of Lightmatter is looking at using photons rather than electrons to carry info and logic around a circuit with lower power losses.Stan Williams has spent much of his career thinking about new devices that could be fabricated into integrated circuits to give it all a push forward. And he tells Roland how the memristor could effectively bring the power of analogue computing to bear as we reach some of the limits of the digital age we have been living in.Presenter: Roland Pease Producer: Alex Mansfield and Gareth Nelson-Davies
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29:07
Researching pain, painlessly
Pain, particularly chronic pain, is hard to research. New therapeutics are hard to screen for. Patients are not all the same. Sergui Pascu and colleagues at Stanford university have been growing brain samples from stem cells. Then they began connecting different samples, specialised to represent different brain regions. This week they announce their most complex “assembloid” yet, one that even reacts to hot chilli, passing a signal from the sensory neurons through to the thinking bits. The hope is that it can provide insights on how pain, and potential painkillers, work.Human brains are notoriously large, particularly infants. Whilst for primates the human pelvis is quite narrow, to allow us to walk and run on two legs. This notoriously makes childbirth, well, not as straightforward as most other species. This evolutionary “obstetric dilemma” has been debated for decades. Marianne Brasil, of Western Washington University, and colleagues, have published this week a huge study of contemporary human genes and anatomies available from the UK Biobank to shed some more light on this ongoing compromise.Malta is an island in the Mediterranean no less than 80km from land. So how come Eleanor Scerri and colleagues have discovered archaeological evidence of hunter-gatherers living there from 8,500 years ago? And they didn’t just visit and leave. They stayed for perhaps a millennium before farming arrived. Maybe a rethink of what nautical capabilities our ancestors had in the deep past is needed? A year ago, Science in Action gate-crashed a conference looking at plans for meeting the forthcoming arrival of asteroid Apophis in 2029. This year the meeting is in Tokyo, and Richard Binzel, emeritus professor of Astronomy at MIT, gives us an update on how the space agencies are hoping to collaborate to maximise the scientific value from what will be a global, visible, phenomenon in just 4 years. Is there enough time to get our collective wits together?(Image: 3D illustration of Interconnected neurons with electrical pulses. Credit: Getty Images)Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Josie Hardy
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43:03
Earthquakes and the first breath of life on Earth
How Myanmar’s tragic earthquake left a 500km scar on the surface of the earth in just 90 seconds. Also, more hints of a link between shingles vaccines and reduced dementia, and how earth’s first oxygen breathers seem to have evolved way before there was enough oxygen to breath.Judith Hubbard is a seismologist and earthquake analyst who has been gleaning what scientific information we can find on the tragic quake that struck Myanmar last week. There seems to be some sort of link between the herpes virus that causes shingles and some people’s risk of Alzheimer’s dementia. At least, the latest paper appears to confirm so, according to an analysis published in Nature this week. Pascal Geldsetzer of Stanford University and colleagues have looked at data from public health records in NHS Wales in the UK, and have retrospectively performed a “natural experiment”, finding a clear suggestion that a vaccine against the virus that causes shingles seems to confer a lower likelihood of developing dementia over the subsequent seven years. Quite why this happens remains moot.And a long time ago, and for a long time, life on earth was nought but bacteria. The atmosphere was also nearly devoid of oxygen. These ancient bacteria leave scant fossil records, whilst the rocks show a clear time – known as the Great Oxidation Event – when earth’s atmosphere transformed to something more like the oxygen rich air we breath now. A pervading chicken-and-egg question asks whether the atmosphere changed and life adapted, or did life somehow evolve and transform the atmosphere? A team publishing in Science this week have performed an innovative analysis of bacterial genomes that suggests that the ability to use oxygen in respiration evolved some 900 million years before the atmosphere transformed. The question still stands, but as the team explain, the new analysis provides at least a clear timeline for why we breath the way we do today.Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Josie Hardy(Image: People ride a scooter past the rubble of damaged Buddhist pagoda in Mandalay on April 3, 2025. Credit: Sai Aung MAIN / AFP via Getty Images)
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31:37
Breakthrough antivirals and fresh US grant cancellations
This week, after five years of research, two newly discovered antiviral molecules have been shown to combat coronaviruses. Johan Neyts of the Rega Institute for Medical Research in Leuven outlines how he hopes the new molecule developed by his team might help us deal with emerging pandemics in the future. But as the US halts all Covid related research, will drugs like these ever hit the shelves? Among the grants terminated this week by the National Institute for Health is a programme called AViDD, AntiViral Drug Discovery, supporting 9 independent consortia. Annette von Delft of Oxford University and Ed Griffen of the drugs discovery company MedChemica spoke to us about the overnight shut down of years of work and importance of antiviral development. The longest ever carbon-based molecules have been discovered by the Mars Curiosity rover. Caroline Freissinet of the Laboratoire Atmosphères et Observations Spatiales talked us through the meticulous planning and geological chance that made this possible, and whether these long chain alkanes could be a clue to discovering life on mars. Researchers at Vanderbilt University have been delving into the genetic evolution of horses to discover the mutation that’s behind their runaway metabolic success. Gianni Castiglione explains how a mutation that should have been catastrophic instead helped horses to evolve from the size of dogs to the giant athletic animals we know today. Presenter: Roland Pease Producer: Emily Bird Production Coordinators: Jana Bennett-Holesworth and Josie Hardy(Photo: Two tablets of Roche Pharmaceuticals' Tamiflu. Photo by Nikos Pekiaridis/NurPhoto via Getty Images)
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28:35