This Week in Cardiology

Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. 
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Mechanical Compression Devices for OHCA
·       Mechanical CPR Device Use Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
·       PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
·       CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
·       LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
·       Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest  https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II ACC AF Performance Measures
·       2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3
III Two Critical Appraisals of the recent LAAC trials
·       Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link
·       CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608
ESC Early Preview
·       CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/
·       SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link
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Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I ZEUS Fails
Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial
https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-zeus-trial-2026a1000rlm
ZEUS Trial https://doi.org/10.1001/jamacardio.2025.4491
II Statins and the Elderly
SAGA/SITE trial 10.1016/j.lanhl.2026.100884 External Link
III GLP-1 and CV Risk
SURMOUNT-1 Trial https://www.nejm.org/doi/10.1056/NEJMoa2206038
SURMOUNT-1 Post Hoc Analysis https://www.jacc.org/doi/10.1016/j.jacc.2026.04.044
Reframing GLP-1s as Cardiometabolic Health Drugs: Editorial https://www.jacc.org/doi/10.1016/j.jacc.2026.06.039
IV Radiation Exposure to the Uterus in the EP Lab
Occupational Radiation Safety in EP During Pregnancy https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.080556
Survey: Working in Cath Lab During Pregnancy https://www.surveymonkey.com/share/d5c1edf7-6d99-49d4-a9fa-e9168f63ab55
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Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
II Another Failure of Posterior Wall Isolation
CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link
III First Line AF ablation – One new study and a discovery about a second one
Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link
EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet
IV Left Atrial Appendage Closure Meta-analysis
Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567
V Prevention of AKI after Cardiac Surgery: MERCURI-2
MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324
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The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
 
I Enlicitide Approved
First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https://www.medscape.com/viewarticle/first-oral-pcsk9-inhibitor-welcomed-potential-primary-care-2026a1000own
Dr Gregory Katz Substack https://gregorykatz.substack.com/p/are-we-sure-mercks-new-cholesterol
CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002
CORALreef HeFH Trial https://jamanetwork.com/journals/jama/fullarticle/2841258
CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756
II MRI Scans in Non-conditional CIEDs
Specialized Nurse Practitioners Safely Manage MRI in Patients With Cardiac Implantable Devices https://www.medscape.com/viewarticle/specialized-nurse-practitioners-safely-manage-mri-patients-2026a1000ozt
Nurse Practitioner-Led CIED Monitoring During MRI 10.1016/j.hroo.2026.04.031 External Link
MRI in Nonconditional Pacemakers and ICDs https://academic.oup.com/europace/article/22/2/288/5717383
Heart Rhythm Society Consensus Document 10.1016/j.hrthm.2017.04.025 External Link
III PFA-SHAM trial
PFA-SHAM Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
IV Orthopedic Injuries in Cardiology
What Will It Take to Make Fluoroscopy Labs Safer?
https://www.medscape.com/viewarticle/what-will-it-take-make-fluoroscopy-labs-safer-2026a1000ox6
Expert Consensus Statement on Enhanced Radiation Protection https://www.jacc.org/doi/10.1016/j.jcin.2026.06.011
'Shed the Lead' and the Injuries. Should Cath Labs Go Lead-Free? https://www.medscape.com/viewarticle/shed-lead-and-injuries-should-cath-labs-go-lead-free-2024a1000hnb
Health Hazards of Working in the Interventional Laboratory https://doi.org/10.1016/j.jacc.2014.11.056
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DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Antiplatelet Therapy After Stenting
DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
HOST-EXAM Trial at 2 years https://pubmed.ncbi.nlm.nih.gov/34010616/
HOST-EXAM Trial at 10 years 10.1016/S0140-6736(26)00422-8 External Link
Nick Kurzen on X https://x.com/ncurzen/status/2077676739463922151
II Aspirin Proves Its Mettle After Hip and Knee Replacement
EPCAT III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603649
CRISTAL Trial https://jamanetwork.com/journals/jama/fullarticle/2795528
III New (and old) Knowledge in Sudden Cardiac Death
Sudden Cardiac Death and its Relation to Cardiac Disease at Autopsy https://doi.org/10.1016/j.jacc.2026.01.029
Sudden Cardiac Death Due to MI With Obstructive and Nonobstructive Coronary Arteries https://doi.org/10.1016/j.jacc.2026.01.030
Frequency of Sudden Cardiac Death and Profiles of Risk https://www.ajconline.org/article/S0002-9149(97)00477-3/fulltext
IV Heart Failure Diagnosis
AHA/ACC/ESC/WHF Expert Consensus Document http://jacc.org/doi/10.1016/j.jacc.2026.05.036
V NICE Makes a Dumb Decision
NICE Recommends New Nonsteroidal MRA for Heart Failure
https://www.medscape.com/viewarticle/nice-recommends-new-nonsteroidal-mra-heart-failure-2026a1000nzv
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