Oxford Sparks Big Questions

• Could vaccinations stop people from getting cancer?

  Finding a cure for cancer is unarguably one of the biggest medical challenges that we face. But what if we could find a way to prevent cancer before it even starts? In this special extended edition of the Big Questions Podcast, we chat to Professor Sarah Blagden, an experimental oncologist at the University of Oxford, and Anna Fry, who has the cancer predisposing condition Lynch Syndrome - putting her at increased risk of developing colorectal and other cancers. Sarah explains how clinical trials of vaccines targeting 'pre-cancer' could revolutionise the fight against cancer, beginning with those at greatest risk.

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• Why do I bite my nails?

  Many of us will be familiar with Body-Focused Repetitive Behaviours (BFRBs), perhaps without even realising it. Such behaviours - which include hair-pulling, nail biting and skin picking - can not only cause physical harm, but also often bring feelings of shame. Because of this, open discussion around BFRBs has been limited. In this episode of The Big Questions Podcast, we chat to Prof Clare Mackay from Oxford's Department of Psychiatry, who both studies and lives with BFRBs. 

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• How do you find a theoretical particle?

  How do you detect a particle that emits no light - in other words, something invisible? This is the intriguing challenge faced by scientists hunting for 'dark matter'. In our series finale, we talk to Elizabeth Bloomfield from Oxford's Department of Physics about dark matter, how we know it exists, and why her research is taking her deep beneath a mountain in Italy in the quest to find it.

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• Is there a better way to screen blood?

  What's the best gift you can give? To the millions of people whose lives have been saved by complete strangers, the answer would be simple: blood. But what exactly happens when blood has been donated, and how do we know it is safe? We chat to Dr Richard Mayne from Oxford's Experimental Medicine Division about genomics, Next-Generation Sequencing, blood screening (...and Star Trek).  Could you be a blood-donating hero? Blood stocks are currently critically low, with the NHS Blood and Transplant (NHSBT) group in urgent need of new donors. Click here, and you'll be on your way to saving lives: https://www.blood.co.uk/news-and-campaigns/campaigns/blood-donor-appeal/

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• How does Ozempic actually work?

  Whether you've been served an advert for it, or just heard about it in the media, it's likely that 'Ozempic' isn't a totally unfamiliar word. Now often associated with weight-loss, Ozempic is actually the brand name for a drug used to treat diabetes. So what exactly is it, how does it work, and is it safe? We chat to diabetes and endocrinology (hormone) expert Dr Annie de Bray to find out.  

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