Peptide of the Week | Weight Loss, Health & Wellness

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/
Peptide Of The Week Socials: https://hoo.be/peptideoftheweekpodcast 

Join The Community: https://www.skool.com/peptideresearchinstitute/about
 
Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/
 
Warrior Coaching: https://www.warrior-makerscoaching.com
 
Peptide Of The Week Website: https://peptideoftheweekpod.com
 
Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
 
JD Denham and William T. Haas go all in on a dedicated TRT episode covering five of the most common hormone questions they get. From a 21-year-old with great total testosterone but terrible free test, to a guy down 115 pounds wondering if he even needs TRT, to the real answer on ball shrinkage and what HCG actually does about it. Plus Dave Palumbo and Alex Diego are coming on the podcast soon and JD announces the upcoming gear deep dive episode.
 
🔬 Topics Covered
• 21-year-old with total T of 970 but free test of only 5.6: what is actually going on and what to do about it
• Why fasting too hard and eating too little is silently killing your free testosterone at any age
• Down 115 pounds at 43 with total T of 635: can you actually be hormonally optimized without TRT?
• What does hormone optimization actually mean and why does every single peptide work better when you are there
• Why low testosterone is probably behind your anxiety, brain fog, depression and lack of sex drive and not just aging
• Is 1200 total testosterone too high and is 800 too low: the real answer for a 56-year-old on TRT
• Total testosterone is only a quarter of the picture: why free T, estrogen, SHBG and LH tell the real story
• Ball shrinkage on TRT: is it real, how bad does it get, and what does HCG actually do about it
• Should a 44-year-old switch from CJC and Ipa to actual HGH and should he start TRT based on blood work alone
• Why 10,000 steps a day is a lot harder than you think and why walking after every meal changes everything 

Chapters:
00:00 – Intro
00:09 – Welcome Back & Hawaii Recap
00:39 – China Trip & Why Addicts Can Do Big Things
03:44 – Finding Your Path & Becoming a Student of Your Craft
07:22 – New Q&A Format: Structured TRT Questions
08:19 – Q&A: High SHBG & Low Free Testosterone at 21
15:57 – Q&A: Should a 48-Year-Old With 582 Total T Start TRT?
20:48 – The 10,000 Step Reality & Post-Meal Walks
25:43 – Q&A: What Does Hormone Optimization Actually Mean?
33:14 – Signs of Low Testosterone & Benefits of Optimizing
38:15 – Upcoming Guests: Palumbo, Alex Diego & a Mold Specialist
42:10 – Q&A: What Is the Optimal TRT Level at 56?
46:15 – Total vs. Free Testosterone: The Bank Account Analogy
47:58 – Q&A: Testicular Shrinkage on TRT & HCG
56:15 – Outro: Gear Episode Plans & Coaching Program

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Follow us on social media:
JD's Socials: https://hoo.be/jddenhamofficial
Will's Socials: https://hoo.be/williamthaas
Peptide Of The Week Socials: https://hoo.be/peptideoftheweekpodcast

Join The Community: https://www.skool.com/peptideresearchinstitute/about

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Warrior Coaching: https://www.warrior-makerscoaching.com

Peptide Of The Week Website: https://peptideoftheweekpod.com

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Part two with Michael Farber goes deep on FLGR-242, the long acting myostatin inhibitor he invented that is helping people gain 10 to 12 pounds of lean muscle in three to four months, without anabolics, without side effects, and regardless of genetics. This is one of the most important muscle building conversations we have ever had on this podcast.

🔬 Topics Covered:
• Why Farber invented FLGR-242 after losing 2+ years of muscle during COVID
• What myostatin actually is and why it is your body's brake on muscle growth and fat burning
• Belgian blue cows, super mice, and real world examples of myostatin mutations
• Why naturally gifted athletes often have partial myostatin mutations and do not even know it
• How FLGR-242 levels the playing field for people not born with athletic genetics
• Expected results: 10 to 12 pounds of lean muscle in 3 to 4 months at 5mg per week
• Why going above 10mg per week produces virtually no additional gains
• Farber personally went to 20mg per week and confirmed no negative health effects above 10mg
• How FLGR-242 was designed to bind ONLY myostatin and why that makes it so safe
• Why Follistatin-344 causes random growth and must be injected locally while FLGR-242 freely circulates
• Brian Johnson's myostatin experiment in Honduras: 2% gain in a year at $50,000 per try
• FLGR-242 vs circular DNA myostatin inhibitors: not even close
• Apelin-13: the ergogenic compound that optimizes fat burning and cardiovascular output simultaneously
• Long acting Thymosin Alpha-1 and Thymosin Beta coming soon
• Bioline: the new appetite and metabolism compound coming down the pipeline
• The albumin binder platform and why it is changing how every compound performs

Chapters:
00:00 – Intro
00:09 – Welcome Back & Will's Mom Moving to Town
01:24 – Appreciating Your Parents While You Have Them
03:29 – Round Two With Michael Farber: Why He Created FLGR-242
06:27 – Myostatin Inhibition Beyond Muscle: Obesity & Fetal Growth
10:02 – Leveling the Playing Field for Natural Athletes
12:21 – Real-World Results: 10–12 Pounds of Lean Muscle in 4 Months
14:44 – Dosing: Why More Than 10 mg a Week Doesn't Help
19:23 – How FLGR-242 Differs From Follistatin 344
24:06 – Safety Record & Gene Therapy Alternatives
27:55 – What's Next: Apelin, Long-Acting Thymosin & Obesity Compounds
30:16 – The Albumin Binder Discovery: MC4R & Amylin Compounds
34:34 – Cancer Drug Trojan Horse Idea
36:40 – Upcoming Launches: Appetite Control & Long-Acting Thymosin Alpha-1
38:44 – Outro

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/ 
Will's Instagram: https://www.instagram.com/williamthaas/
Peptide Of The Week Socials: https://hoo.be/peptideoftheweekpodcast 

Join The Community: https://www.skool.com/peptideresearchinstitute/about
 
Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/
 
Warrior Coaching: https://www.warrior-makerscoaching.com
 
Peptide Of The Week Website: https://peptideoftheweekpod.com
 
Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
 
JD Denham is live from Maui on his honeymoon while William T. Haas holds it down in the studio. This week they go deep on growth hormone in all its forms covering HGH timing for normal vs reduced pituitary function, whether stacking Tesamorelin on top of HGH is a waste of money, how to run your first steroid cycle properly, why FLGR 242 is the first compound JD says can genuinely compete with gear, and what carpal tunnel symptoms after adding Ipamorelin actually mean.
 
🔬 Topics Covered
• Why taking HGH at night could be silently sabotaging your biggest natural growth hormone pulse
• Is stacking Tesamorelin on top of HGH a waste of money or does it still do something unique?
• Carpal tunnel and joint pain after adding Ipamorelin at only 200mcg: bad sign or great sign?
• Running your first steroid cycle with Test and Primo: why stopping at 8 weeks is the worst mistake you can make
• Should you add FLGR 242 or IGF-1 LR3 to a steroid cycle and what actually happens when you do? • Why taking HGH on workout days only and skipping rest days is completely backwards
• MK-677 vs Ipamorelin: why one will make you eat everything in sight and the other probably won't affect your hunger at all
• Can you stack HGH, MK-677 and IGF-1 LR3 together or is that just overkill?
• Why Klotho may be the most underrated compound for anyone running gear and what it is actually doing for your kidneys
• Every single person listening should be taking glutathione and here is exactly why 

Chapters:
00:00 – Intro
00:09 – Welcome Back & Live From Maui
01:49 – Why Vacation and Rest Matter
03:20 – How Muscle Actually Grows: Recovery & HGH Timing
04:58 – Training Intensity, Dorian Yates & Muscle Group Splits
11:12 – Steroids Don't Replace Hard Work
13:49 – Why Legs, Back & Deadlifts Matter
17:10 – China Trip & Shoutout to the Team
18:35 – Buying a Whole American Wagyu Cow
22:01 – Q&A: HGH vs. Secretagogues for a 34-Year-Old Woman
28:46 – Q&A: Ipamorelin Carpal Tunnel & Joint Pain
34:19 – Q&A: Stacking HGH With Tesa, Ipa & Sermorelin
41:35 – Q&A: Peptides While Running Test & Primo
56:10 – Q&A: HGH, MK-677 & IGF-1 LR3 Timing
1:03:11 – Q&A Format Feedback, Skool & Outro

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Follow us on social media:
JD's Socials: https://hoo.be/jddenhamofficial
Will's Socials: https://hoo.be/williamthaas
Peptide Of The Week Socials: https://hoo.be/peptideoftheweekpodcast

Join The Community: https://www.skool.com/peptideresearchinstitute/about

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Warrior Coaching: https://www.warrior-makerscoaching.com

Peptide Of The Week Website: https://peptideoftheweekpod.com

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

This is not a conversation about peptides. This is a conversation with the man who invented two of the most talked about longevity compounds on the planet. Dr. Michael Farber joins JD Denham and William T. Haas to break down Klotho and FLGR-242 from the ground up. Who created them, why he created them, how they actually work in the body, and where medicine is heading in the next 20 years.

 🔬 Topics Covered:
• Who is Dr. Michael Farber and his 35 years in biochemistry and 150 patents
• Why he invented Klotho to save his own kidney after losing his right kidney in his teens
• How Klotho regulates phosphate and calcium and why that matters for kidney function
• The feedback loop of kidney disease that has never been reversible until now
• People going from an EGFR of 40 back up to 70 and beyond on Klotho
• Why Klotho makes NAD work dramatically better through the SIRT1 pathway
• Klotho and the blood brain barrier: clearing toxic plaque buildup without entering the brain
• Why Dr. Farber considers Klotho more important for longevity than FLGR-242
• How the albumin binder platform works and why it allows bi-weekly dosing
• Klotho dosing: 10 micrograms every two weeks for healthy individuals, every 11 to 12 days for kidney dysfunction
• What happens if you overdose Klotho and why it is strictly range-bound
• FLGR-242: the long-acting myostatin inhibitor that is outperforming all expectations
• Why FLGR-242 dosing is nothing like Follistatin-344 and must not be confused
• The future of medicine: synthetic organs, CRISPR, fetal genetic optimization, and living to 120
• Dr. Farber consumed a bottle of painkillers a week for decades. In the last 18 months he has taken two or three total.

Chapters:
00:00 – Cold Open: Living With Kidney Disease for 40 Years
00:45 – Intro
00:54 – Welcome Back & Meeting Dr. Michael Farber
02:50 – Why He Created Klotho: Losing a Kidney
05:10 – Klotho Results: 10 mcg & Rising eGFR
07:34 – The Albumin Binder Breakthrough
12:28 – How Klotho Works in the Body
14:53 – Klotho, NAD+ & FLGR-242 Synergy
20:13 – Cardiovascular Health & Restored Libido
21:54 – Klotho Dosing: 10 mcg Every 11–14 Days
24:52 – Separating Hype From Reality
27:14 – Overdose Risks & Checking Urine Output
29:42 – Feeling "Reborn": Life After Kidney Disease
36:30 – The Future of Longevity: Organs & CRISPR
45:12 – Outro & Part 2 Preview

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.

Follow us on social media:
JD's Instagram: https://www.instagram.com/jddenhamofficial/
Will's Instagram: https://www.instagram.com/williamthaas/
Peptide Of The Week Socials: https://hoo.be/peptideoftheweekpodcast

Join The Community: https://www.skool.com/peptideresearchinstitute/about

Subscribe to our Newsletter: https://potwnewsletter.beehiiv.com/

Warrior Coaching: https://www.warrior-makerscoaching.com

Peptide Of The Week Website: https://peptideoftheweekpod.com Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

JD Denham and William T. Haas sit down for a focused all-R episode covering the most common questions they get about "R". From whether you actually need to stop between cycles, to building a stack from scratch as a brand new female, to using R with breast cancer history, to whether Cagrilintide is worth bridging with over the holidays. Plus Dr. Mike Farber, creator of FLGR 242 and Klotho, is coming on the podcast next week and JD has been running FLGR long enough to say it is giving gear a serious run for its money.

🔬 Topics Covered
• Do your R receptors actually burn out and do you need to cycle off?
• The best way to time your R doses around the weekend when cravings hit hardest 
 Building a peptide stack from absolute zero as a 33-year-old female athlete
• Why taking too many peptides at once is costing you money and answers
• Hormone breast cancer history on R: what is safe and what is not
• Why fatigue on R almost always comes down to one thing nobody wants to hear
• AOD vs Tesamorelin vs HGH for a 45-year-old male trying to lose his last 20 pounds
• Does 5-Amino-1-MQ actually block NAD or is that completely backwards?
• The cognitive and fat burning stack for a 40-year-old Marine on TRT and R
• FLGR 242 is the first peptide JD says is genuinely giving gear a run for its money

Chapters:
00:00 – Cold Open: Should You Stop "R"?
01:00 – Intro
01:09 – Welcome Back & VIP Zoom Call Updates
03:44 – Website, Trusted Sources & Coaching Updates
04:59 – Upcoming Guest: Dr. Mike Farber (FLGR-242 & Clotho)
08:21 – Q&A: Bridging Between "R" Cycles With Cagrilintide
15:24 – Q&A: Building a Peptide Stack as a Beginner
28:22 – Q&A: Low Energy on Reta After Breast Cancer
38:22 – Q&A: AOD-9604 & CJC After Major Weight Loss
46:18 – Q&A: Do 5-Amino-1MQ & NAD+ Conflict?
51:41 – Outro & Next Episode Preview
52:46 – "R" Takeaways Recap

Become a supporter of this podcast: https://www.spreaker.com/podcast/peptide-of-the-week-weight-loss-health-wellness--7447107/support.