The Human Upgrade with Dave Asprey

• Why Most Supplements Are a WASTE of Money (And What Actually Works) : 1291

  Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jeff Boyd, founder of MTE and a leader in the new wave of performance supplements. With a background in data-driven wellness and a decade of experience optimizing human performance without caffeine or sugar, Jeff breaks down the science of nootropics, adaptogens, and smart nutrient stacking. His work focuses on self-quantification, nervous system regulation, and sustainable energy for founders, athletes, and high performers. Together, they explore why 85% of supplements are designed to fail, how to activate mitochondria for real results, and what it means to biohack your biology smarter, not harder. This isn’t just about supplements. It’s about reclaiming your energy, upgrading your brain, and aligning your stack with how your body actually works. You’ll also hear how fasting, sleep optimization, and even subtle neurohacking protocols support long-term resilience and better decision-making. You’ll Learn: • The real reason most supplements don’t absorb and how to fix it • How to build a caffeine-free stack that fuels energy, mood, and clarity • The latest in adaptogens, nootropics, and functional medicine • How to align your supplement timing with circadian biology and ketosis • Why “clean labels” often mean nothing • How emotional regulation and neurotransmitters shape performance • Tools for self-quantification and supplement personalization This is essential listening for anyone serious about biohacking, longevity, smarter supplementation, mitochondrial health, sleep optimization, emotional resilience, and conscious human performance. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks questions no one else dares and brings you real tools to become more resilient, aware, and high performing. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • MTE website – www.getmte.com • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:13 Saffron Benefits • 02:26 Medicinal Herbs • 04:12 Supplement Formulation • 13:16 Theanine & GABA • 20:06 Adaptogens & Performance • 23:23 Stress & Muscle Growth • 24:03 Parenting & Energy • 27:47 Nervous System for Kids • 35:15 Sleep for Families • 36:41 Wrap-Up & Offers See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  43:21
• Can Injectable MDMA Become the Next Biohack in 2026? RFK Jr. vs FDA – Rick Doblin : 1290

  Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what’s really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Rick Doblin, PhD, the legendary founder of MAPS and one of the most influential figures in psychedelic science. With nearly 40 years leading clinical research on MDMA, psilocybin, and trauma healing, Rick brings unmatched insight into how these compounds are transforming functional medicine, emotional resilience, and neuroplasticity. They break down the regulatory battle over MDMA therapy, the clash between pharmaceutical profit and public benefit, and the urgent need to combine pharmacology with therapy for real results. You’ll also learn how psychedelics impact neurohacking, epigenetics, and the default mode network—and why the next frontier of self-transformation may be couples therapy with MDMA. This episode offers critical knowledge for anyone serious about biohacking, trauma release, mental performance, and accessing deeper states of healing. This podcast channel dives into the intersections of psychedelics with fasting, ketosis, cold therapy, and self-quantification—and how altered states can unlock more energy, better relationships, and lasting change. You’ll Learn: • Why separating therapy from psychedelics is the most dangerous path forward • How MAPS evolved into a public benefit pharma company—and what went wrong • The real story behind the FDA’s rejection of MDMA therapy in 2024 • How MDMA affects neuroplasticity, mitochondria, and trauma recovery • Why group therapy and couples therapy are the future of psychedelic healing • The dangers of overusing ketamine—and how it’s being exploited by profit-driven clinics • What the Psychedelic Science 2025 conference will reveal about the future of medicine, spirituality, and consciousness hacking • How psychedelics could reverse epigenetic trauma passed down through generations • The role of default mode network suppression in spiritual experiences and trauma resolution • Why the war on drugs was never about safety—and what a post-drug-war world might look like Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, neurohacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Psychedelic Science Conference 2025 Website – https://www.psychedelicscience.org/ • Rick’s Website: https://maps.org/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 02:00 Intro • 03:43 Rise of Psychedelic Pharma • 05:00 Therapy vs. Profit • 06:44 Neurofeedback + Psychedelics • 08:28 Origins of Drug Laws • 14:06 MDMA Safety + Usage • 16:32 Psychedelics in Therapy + Meditation • 25:18 Psychedelic Hierarchy for New Users • 26:51 Psychedelic Churches + Culture • 28:58 Ayahuasca: Spiritual Insights • 30:24 MDMA and Federal Policy • 31:09 Inside the FDA Decision • 32:52 Therapeutic Promise of Psychedelics • 34:43 Psychedelics + Spirituality • 37:37 Neuroscience of Psychedelics • 40:12 Epigenetics + Generational Trauma • 43:50 War on Drugs Revisited • 46:37 Future of Legalization • 49:55 MDMA for Couples • 51:29 Group Therapy with Psychedelics • 52:26 Psychedelic Science 2025 Preview See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  53:28
• Should You Eat Dirt? The “Healthy” Foods Destroying Your Gut – Dr. Josh Axe : 1289

  You’ve been told to eat clean, but what if your “healthy” foods are wrecking your gut, crushing your hormones, and aging you faster? This episode exposes the nutrient-depleted truth behind modern diets, soil erosion, and why regenerative farming might be the key to reversing chronic disease, boosting mitochondria, and rebuilding your biology from the ground up. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Josh Axe, a trusted pioneer in functional medicine, bestselling author, and co-founder of Ancient Nutrition. Dr. Axe bridges the gap between biblical farming, ancestral nutrition, and modern science to explain how your food and even your supplements may be harming your human performance, digestion, and brain health. With clinical insights, personal stories, and science-backed tools, he shares what to eat instead if you want real longevity, energy, and healing. They dig into the collapse of soil nutrients, how monocropping damages the microbiome, and why organic food standards may be outdated. You’ll learn how regenerative agriculture rebuilds the earth and your gut, and why biohacking starts with dirt, not pills. Plus, they explore the hormonal chaos caused by seed oils, plastics, blue light, sleep disruption, and even birth control, especially in relation to testosterone loss in men and women. This episode also touches on biblical nutrition, fasting cycles, natural nootropics, testosterone-supporting peptides, the dangers of synthetic vitamins, and the future of real-time self-quantification. From poop-powered farming to smarter sourcing, it’s a wild ride into how food, faith, and farming affect every part of your biology. This is essential listening for anyone serious about biohacking, neurohacking, longevity, Upgrade Labs, Danger Coffee, Smarter Not Harder, and understanding the real root of disease and dysfunction. You’ll Learn: • Why regenerative farming beats “organic” for health and the planet • How depleted soil is linked to hormone imbalances and chronic disease • What birth control is doing to testosterone, fertility, and mitochondrial health • Why your supplements may just be “expensive pee” • The truth about biblical farming and why dirt still matters • How to support testosterone naturally with diet, peptides, and habits • Why sleep optimization, mineral balance, and circadian alignment are key for healing Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. - Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Josh Axe’s Website – https://thehealthinstitute.com/ • Josh Axe’s Instagram: https://www.instagram.com/drjoshaxe/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:52 Intro • 01:01 From Medicine to Farming • 02:21 Regenerative Farming • 03:36 Fixing Modern Agriculture • 05:43 Biblical Farming Meets Modern Science • 08:23 The Truth About Organic Food • 12:41 What’s Causing the Testosterone Crash • 18:07 Hormonal Birth Control • 27:37 New Hormone Replacement • 29:58 The Future of Health Tracking • 32:00 What Is Biblical Farming? • 33:38 Biblical Principles of Nutrition • 33:55 Foods Most Mentioned in the Bible • 35:17 Pork, Parasites, and Dietary Laws • 37:29 Chinese Medicine’s View on Pork • 39:36 Did the Flood Shorten Human Lifespan? • 42:26 Biodynamic Farming and Spirituality • 54:27 Fatherhood and Words That Heal • 56:21 What Josh Feeds His Kids • 01:03:41 Mental Health, Faith, and Healing • 01:05:36 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:05:58
• How 5G Affects Brainwaves (and the New Science to Fix It) : 1288

  Your brain is under constant assault from devices you use every day. This episode reveals the hidden effects of 5G on brain function, cognitive performance, and nervous system stress, along with the science-backed method that neutralizes the damage. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Philipp Samor von Holtzendorff-Fehling, founder of Quantum Upgrade and a former VP at T-Mobile, to explore groundbreaking EEG research that shows how EMF exposure disrupts brainwaves in real time. Philipp shares how new tools are changing the way we approach biohacking, human performance, and energy medicine, and why even hardcore skeptics are paying attention. They break down double-blind studies, ATP production, and real-world EMF mitigation techniques that support brain health, mitochondrial resilience, and recovery. You’ll hear why professional athletes, clinicians, and even animals are benefiting from non-invasive approaches once dismissed as fringe, and how to evaluate what actually works in your own biology. This conversation is essential for anyone focused on biohacking, self-quantification, neurohacking, longevity, functional medicine, Upgrade Labs protocols, and protecting the brain in a wireless world. Whether you’re optimizing your nervous system, improving sleep, or just trying to stay sharp in a high-EMF environment, this episode gives you a toolset to reclaim your state. You’ll learn: • What EEG brain scans reveal after just 30 minutes of 5G exposure • Why ATP production increases in certain energetic fields • How energy fields influence brainwaves, stress, and performance • The connection between EMFs, mitochondrial function, and resilience • Why placebo doesn’t explain these results and what that means for self-tracking • How to use energetic tools alongside Danger Coffee, cold therapy, fasting, and nootropics Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. - Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Quantum Upgrade Website – Go to https://quantumupgrade.io/Dave for a free trial. • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Quantum Upgrade Instagram: https://www.instagram.com/quantumupgrade.io/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:54 Intro • 01:18 Resistance to Energy Work • 03:25 Inner Intuition • 04:22 Science vs Experience • 09:12 Quantum Effects on Body • 13:43 Biohacking for Pets • 15:43 EMFs & Quantum Upgrade • 23:39 Explaining Quantum Tech • 27:58 Understanding Frequencies • 28:53 Scientific Proof & Use • 31:07 Brain Support Tools • 32:28 Ethics & Consent • 34:09 EMF Defense & Biofield • 39:07 Meditation & Altered States • 46:59 Performance Optimization • 48:02 Science Catching Up • 50:39 Free Trial & How to Try See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  52:54
• Mark Sisson: The Japanese Walking Hack That Outperforms 10,000 Steps A Day : 1287

  Most people think 10,000 steps a day is the gold standard for health, but it’s outdated, inefficient, and often damaging. In this episode, you’ll discover a smarter, faster way to walk for longevity, fat burning, and total body resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Mark Sisson, bestselling author, primal health pioneer, and founder of Primal Kitchen. With over 40 years at the forefront of fitness and ancestral health, Mark has helped millions rethink everything they thought they knew about cardio, running, metabolism, and movement. He was one of the first to challenge the chronic cardio myth, helped popularize ketosis and fat-adapted performance, and now returns with a new message: walking right, not more, is one of the most powerful biohacks for human performance and aging. They dive into the Japanese walking interval method that outperforms 10,000 steps, and explore the critical link between foot health, barefoot shoes, and the brain-body connection. Mark also shares why he trains just 20 minutes a week, why too much saturated fat might backfire, and why performance should never come at the cost of your mitochondria. You’ll learn how to build muscle and endurance with less effort, how to reverse foot dysfunction with every step, and how to age with strength, intuition, and freedom. This episode hits hard on biohacking, functional movement, longevity, self-quantification, and the real science of walking smarter, not longer. It’s also packed with insights on ketosis, nootropics, sleep optimization, and why perfectionism ruins health gains. If you’re serious about Smarter Not Harder strategies, tuning into your body, and reclaiming your natural performance potential, don’t miss this one. You’ll learn: • Why zone 1 walking beats zone 2 training for longevity • How foot dysfunction leads to systemic breakdown • The hidden brain-glute-big toe connection no one talks about • Why Mark no longer runs or eats ribeyes • The minimum effective dose for strength, mobility, and fat burn • Why perfectionism in wellness is toxic and what to do instead Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. **Go to www.peluva.com and use code ‘DAVE’ for 15% off ** SPONSORS: - LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Resources: • Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Mark’s Website – www.peluva.com • Mark's Instagram: https://www.instagram.com/wearpeluva/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 00:43 – Intro • 01:13 – Mark’s entrepreneurial journey • 04:53 – The rise of health blogging • 05:40 – Why cardio might be hurting you • 17:53 – Foot health and performance • 20:54 – Barefoot and minimalist footwear • 33:30 – Launching PVA Shoes • 42:59 – Diet’s role in foot recovery • 43:38 – Why comfort matters in footwear • 44:12 – Personal footwear hacks • 45:03 – Building a footwear brand • 46:21 – Fashion vs function in foot health • 49:17 – Simple foot strengthening tools • 52:35 – What history reveals about shoes • 58:47 – Walking and brain optimization • 01:06:41 – Protein, aging, and nutrition • 01:19:50 – Longevity and biohacking wins See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

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  1:22:37

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