The Human Upgrade: Biohacking for Longevity & Performance

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omic testing, biohacking technology, and longevity science to optimize every layer of your biology.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity Equation, and President and Founder of the American Board of Precision Medicine. He serves as Adjunct Professor at the George Washington University School of Medicine and CEO of the Institute for Human Optimization. Dr. Bajnath is certified through the Institute for Functional Medicine, board certified in anti-aging and regenerative medicine, and is one of the few clinicians actively applying genomics, transcriptomics, proteomics, and epigenetics together in a real clinical practice.

Together, Dave and Dr. Bajnath break down why population-based medicine fails individuals, how functional medicine and precision science combine to unlock real human performance, and why your mitochondria sit at the foundation of every longevity strategy worth pursuing. They dig into how AI can help you decode your own inflammasome biology, why biohackers are using “sex drugs” to extend longevity, why vagal nerve stimulation directly suppresses the NLRP3 inflammasome, and which biomarkers like MMP9 and homocysteine mainstream medicine keeps ignoring. They also cover peptides, supplements, the dark side of metformin, microdosing for anti-aging, and why biohacking works best when it's personalized and precise.

This is essential listening for anyone serious about longevity, smarter not harder health strategies, metabolism, sleep optimization, brain optimization, functional medicine, and taking full control of their biology.

You'll Learn:
Why precision medicine outperforms population-based health strategies for human performance
How to layer genomics, transcriptomics, and proteomics into one complete biological picture
Which longevity biomarkers your doctor is likely ignoring, including MMP9 and homocysteine
How vagal nerve stimulation suppresses the NLRP3 inflammasome and drives anti-aging benefits
The real story on metformin, peptides, and which supplements actually move the needle
How AI can help you understand your own biology and act on it faster
Why biohacking precision beats random stacking every time

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: precision medicine, biohacking, Dave Asprey Cialis, Anil Bajnath, American Board of Precision Medicine, multi-omics, genomics, transcriptomics, proteomics, epigenetics, NLRP3 inflammasome, vagal nerve stimulation, MMP9, homocysteine, mitochondria, longevity, anti-aging, peptides, BPC-157, metformin, rapamycin, functional medicine, human performance, supplements, EGCG, exposome, nitric oxide, vascular health, metabolism, brain optimization, AI health, biohacking technology, Dave Asprey Sex Drugs

Resources:
• Learn More About Anil’s Work And the Institute For Human Optimization At: https://ifho.org/
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Timestamps:
00:00 – Trailer
00:53 – Intro to Precision Medicine
01:58 – Dr. Bajnath's Holistic Health Journey
05:03 – Pharmaceuticals vs. Supplements
07:58 – Peptides and Longevity Molecules
10:34 – Sexual Health and Vitality
13:56 – Vascular Health and Blood Flow
15:14 – Multi-Omics Approach
19:03 – DNA and Genomics
22:17 – Transcriptomics and RNA
24:24 – Proteomics and Inflammation Markers
32:00 – The Human Exposome
34:55 – Key Health Biomarkers
36:58 – Cell Membrane Dynamics
40:28 – Biological Investment Strategy
41:53 – Life Extension Possibilities
48:52 – Bioenergetics and Mitochondria
49:47 – Quantum Medicine and the Future
51:33 – Vagal Nerve Stimulation
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What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?

Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

The twist? You can activate it in just 10 minutes a day, no prescription required.

Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...

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0:00 – Introduction
0:46 – Lobsters and Human Longevity Connection
1:14 – Understanding Telomeres and Aging
2:26 – How Lobsters Defy Aging
3:32 – Rethinking Aging Biology
4:53 – The Telomerase Challenge
6:43 – Natural Ways to Protect Telomeres
9:33 – Meditation's Role in Anti-Aging
11:04 – Different Meditation Techniques
13:19 – Benefits and Long-Term Effects
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This week’s stories:

Sinclair’s This Is the Test: Are we about to see age reversal in humans?

At the World Governments Summit 2026 in Dubai, Harvard geneticist David Sinclair told world leaders that ageing could soon be reversible and said the first human clinical trials of epigenetic reprogramming therapies are moving forward. The core idea is that ageing is partly an information problem, how cells read DNA, not just cumulative damage, and that partial reprogramming could restore youthful function without turning tissues into tumors. Dave frames this as a rare binary moment for longevity: either early, localized human trials (starting with tightly controlled tissue targets like the eye) show meaningful functional rejuvenation with acceptable safety, or the field has to recalibrate fast. Either way, the next couple of years will heavily influence where money, regulators, and serious researchers place their bets.
• Sources:
– World Governments Summit: https://www.worldgovernmentssummit.org/media-hub/news/detail/ageing-could-soon-be-reversible-says-harvard-scientist-at-wgs-2026
– NAD / Life Biosciences coverage: https://www.nad.com/news/fda-greenlights-life-biosciences-human-study-setting-up-pivotal-test-for-aging-theory-from-harvards-david-sinclair


AlphaFold 4 in a locked box: DeepMind’s private AI drug design engine
Isomorphic Labs, DeepMind’s drug discovery company, unveiled a proprietary drug design engine that outside scientists are comparing to an AlphaFold 4 moment, but for designing drugs, not just predicting structures. The big shift is that this system is closed: no public weights, no open database, and access appears to flow through partnerships with pharma companies. Dave breaks down why that matters for the longevity world: if AI makes early discovery cheaper and faster, we might see more serious shots on ageing targets over the next decade, but a closed model can also mean less transparency, bigger IP moats, and no guarantee that faster discovery leads to cheaper drugs.
• Sources:
– Nature: https://www.nature.com/articles/d41586-026-00365-7
– Isomorphic Labs: https://www.isomorphiclabs.com/articles/the-isomorphic-labs-drug-design-engine-unlocks-a-new-frontier

Peptides in the freezer: El Mencho’s anti aging stash and the dark side of wellness

After reports and images from the final hideout linked to Jalisco New Generation Cartel leader Nemesio Oseguera Cervantes (El Mencho), coverage highlighted a detail that feels uncomfortably familiar to anyone in the modern wellness internet: injectable vials stored in a freezer with a schedule attached, including Tationil Plus, a glutathione based injectable marketed in some places for “cellular health,” cosmetic effects, and anti ageing. Dave uses the absurdity as a narrative wedge, not cartel gossip, to talk about how normalized gray market injectables have become, and how marketing (“detox,” “cellular reset”) often outruns evidence and safety. The segment pivots into a practical filter: which compounds are real therapeutics under medical supervision, and which are expensive folklore with sourcing risk and unknown long term downsides.
• Sources:
– New York Post: https://nypost.com/2026/02/25/world-news/inside-the-luxurious-love-nest-where-mexican-drug-lord-el-mencho-spent-his-final-days/
– Sky News (Reuters photos referenced): https://news.sky.com/story/inside-the-mexican-villa-where-feared-drug-lord-el-mencho-spent-final-hours-13511954
– Reuters photo gallery: https://www.reuters.com/pictures/el-menchos-last-hideout-inside-villa-where-cartel-leader-spent-final-hours-2026-02-25/W7DK5WEXS5IMLLZQO2P3CXGXFM


The disease we thought was dead: measles comes roaring back

Measles cases have surged in early 2026, with reporting citing at least 588 cases in the U.S. by late January, already more than many full year totals, and additional updates showing continued acceleration into February. Dave reframes this as a healthspan floor issue: you can argue about peptides and mitochondria all day, but measles is so contagious that once community immunity drops, outbreaks move fast and hit the most vulnerable first, especially infants and immunocompromised people. He also flags the systems problem: many clinicians have never seen measles, which increases the odds of delayed recognition and wider exposure in waiting rooms. The actionable move is boring and high ROI: verify MMR status for you and your family and close gaps before outbreaks get closer to home.
• Sources:
– AMA Morning Rounds (Week of Feb. 2, 2026): https://www.ama-assn.org/about/publications-newsletters/top-news-stories-ama-morning-rounds-week-feb-2-2026
– ABC News (CDC case count coverage): https://abcnews.com/Health/588-us-measles-cases-reported-january-cdc/story?id=129699078
– CIDRAP (case tracking context): https://www.cidrap.umn.edu/measles/us-measles-cases-soar-588-so-far-year-south-carolina-confirms-58-new-infections


DC vs your health: Trump’s State of the Union health reset

President Donald Trump’s 2026 State of the Union included a cluster of healthcare themes that function as a directional signal for agencies and payers this year, including drug pricing rhetoric, price transparency, and broader coverage and affordability framing. Dave translates the politics into a practical heuristic for biohackers: federal posture quietly determines what becomes easy versus painful to access in the legitimate system, from GLP 1 coverage rules and prior auth behavior to how friendly the environment is for telehealth, at home diagnostics, and eventually whatever “real longevity medicine” looks like. You do not need every policy detail in a weekly rundown, just the weather report: reimbursement and enforcement trends shape what stays niche, what scales, and what gets friction.
• Sources:
– Advisory Board: https://www.advisory.com/daily-briefing/2026/02/25/health-policy-roundup
– Healthcare Dive: https://www.healthcaredive.com/news/trump-state-of-the-union-healthcare-2026/812962/
– This Week in Public Health analysis: https://thisweekinpublichealth.com/blog/2026/02/25/the-2026-state-of-the-union-what-it-means-for-health-and-public-health/


All source links are provided for direct access to the original reporting and research.


This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.


New episodes every Tuesday, Thursday, Friday, and Sunday.


Keywords: David Sinclair age reversal, epigenetic reprogramming therapy, Yamanaka factors OSK, Life Biosciences clinical trial, human rejuvenation trial 2026, biological age reset, longevity breakthrough news, DeepMind Isomorphic Labs, AlphaFold 4 drug design, AI drug discovery engine, geroprotective drug development, peptide gray market risks, injectable glutathathione Tationil Plus, GLP-1 regulation FDA warning, wellness industry regulation, measles outbreak 2026 US, MMR vaccine status adults, vaccine trust public health, health policy 2026 State of the Union, GLP-1 access and reimbursement, telehealth longevity care, biohacking news, anti-aging research update


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Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
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Timestamps:
0:00 - Introduction
0:30 - Story #1: David Sinclair 2026
2:13 - Story #2: Google Drug Discovery
3:48 - Story #3: El Mencho Biohacking
5:30 - Story #4: Measles Outbreak
6:51 - Story #5: Trump State of the Union
8:00 - Weekly Roundup
9:10 - Closing
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Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
-Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/

Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptides actually are, how they work in the body, and how to use them without doing something dumb. Josh Felber and Jay Campbell are both cofounders of BioLongevity Labs and longtime leaders in the peptide and performance space. Josh is also the host of the Making Bank podcast and a serial entrepreneur in health. Jay has spent more than a decade researching and teaching advanced peptide protocols and performance strategies.

They break peptides down in plain English as chains of amino acids that act like signaling molecules, then get into what matters in the real world: delivery methods, dosing, and why pharmacokinetics and timing decide whether something works. You’ll hear why peptide pens feel like a huge upgrade over vials and syringes, why Dave wants patches and microneedle tech next, and how convenience can make the difference between consistency and quitting.

Dave and the guys also go deep on mitochondria and longevity. They talk about SS31, now called elamipretide, and why it focuses on mitochondrial membranes and cardiolipin. They cover MOTS-c as a “turbocharger” peptide that people often feel fast, especially if they feel metabolically sluggish. They get into growth hormone peptides like Tesamorelin, Ipamorelin, and CJC, plus why MK-677 sounds convenient but can come with tradeoffs like appetite and other downstream effects.

Then the conversation turns into what’s new. Jay shares what he claims is a new long-acting folistatin-style compound called FLGR 242, designed to stay active for weeks. He frames it as a potential solution for GLP users who worry about losing muscle. They also talk about Klotho, what it does in aging, why it is hard to stabilize, and why Jay believes small dosing matters because of kidney risk at higher levels. Dave ties Klotho back to endothelial function and kidney protection, and they swap stories about what people report noticing.

You’ll Learn:
• What peptides are, explained without jargon
• Why delivery matters and why pens beat mixing vials all day
• How PK curves change real results and dosing schedules
• What elamipretide means for mitochondria and longevity
• Why MOTS-c can feel like a fast energy shift for some people
• How Tesamorelin, Ipamorelin, and CJC fit into growth hormone support
• Why MK-677 sounds easy but can bring unwanted effects
• What Jay claims FLGR 242 does for myostatin, muscle, and fat loss
• Why Klotho shows up in longevity research and why dose matters

Thank you to our sponsors!
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: peptides, biohacking, Dave Asprey, Jay Campbell, Josh Felber, BioLongevity Labs, mitochondrial peptides, elamipretide SS31, MOTS-c, growth hormone peptides, Tesamorelin, Ipamorelin, CJC-1295, MK-677, folistatin, myostatin inhibitor, FLGR 242, Clotho peptide, longevity science, anti-aging, human performance, muscle growth, fat loss, GLP-1 muscle preservation, pharmacokinetics, peptide dosing, nootropics, functional medicine, metabolism, endothelial function, kidney protection

Resources:
• Get a discount from BIOLONGEVITY LABS by using code ‘Dave’ at: https://biolongevitylabs.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
0:00 – Trailer
1:22 – Introduction to Peptides
7:52 – Peptide Delivery Systems & Pens
14:22 – Safety & Regulation of Peptides
19:22 – SS-31 & Mitochondrial Health
26:22 – Blending Peptides & Cross-Linking
38:22 – Growth Hormone Peptides
44:22 – FLGR-242: The New Myostatin Inhibitor
54:22 – Melanin & Consciousness
57:22 – Klotho: The Longevity Peptide
59:25 – Regulatory Landscape & Future of Peptides
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Your skin is not just a cosmetic surface. It’s a living organ that responds to signals, and the right light signal can flip your biology into repair mode.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
-Get a discount from LYMA by using code ‘DAVE10’ at: https://lyma.life/
-Offer not valid on LYMA Laser PRO or LYMA Youth System

In this episode, Host Dave Asprey goes to London to meet Lucy Goff, founder of LYMA, at the LYMA headquarters. Lucy and her scientific team engineered a rare kind of at-home cold laser that delivers precise 808nm light with deep penetration, without burning, cutting, or “damaging to rebuild.” Their work is backed by published research in the Aesthetic Surgery Journal, and they’ve tested gene expression in human dermis, including a reported sixfold increase in SIRT1, a major longevity pathway. This is why you can trust this conversation. It’s not vibes, it’s engineering, biology, and data.

Most “red light” products are basically glorified LEDs. They can be fine for the surface, but they do not deliver the kind of coherent, polarized, monochromatic light that your cells actually respond to in deep tissue. That matters because your mitochondria run the whole show. When mitochondria get a clean signal and more usable energy, your body suddenly has budget for repair, collagen, circulation, and recovery. That is the real mechanism behind anti-aging that does not rely on controlled injury.

We get into how this kind of light hacking can change skin quality, muscle support under the skin, and even scars and fascia. We talk cartilage, knees, jowls, pigmentation, and the weird reality that you might not feel anything while it’s working. Dave also shares his early biohacking experiments using light for brain optimization, including the time he overdid it and temporarily scrambled his speech. That story will make you respect the power of light as a biological tool.

We also talk human performance and travel. Dave breaks down how he uses light management for sleep optimization and jet lag, and why controlling light is as important as controlling food, fasting, ketosis, and metabolism. There’s also a practical angle here that most people miss: with AI, you can now take dense PubMed research and translate it into usable decisions without needing a PhD, which changes how fast you can learn, test, and personalize.

If you care about longevity, neuroplasticity, recovery, and looking younger without trashing your tissue, this episode gives you a smarter way to think about lasers, supplements, nootropics, and the whole functional medicine stack. This is Smarter Not Harder biohacking, with a laser.

You’ll Learn:
• Why LED “red light therapy” is not the same as laser-based mitochondrial activation
• How coherent light influences mitochondria, collagen quality, and anti-aging repair
• What gene expression changes like SIRT1 suggest about longevity signaling
• How light may support brain optimization, circulation, and neuroplasticity
• Why scars and fascia can disrupt performance, and how light can support remodeling
• How Dave uses light and lifestyle hacking for sleep optimization, travel, and metabolism
• How AI makes research-driven biohacking more accessible and more personal

Thank you to our sponsors!
• KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off
• BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
• EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: cold laser therapy, 808nm laser, LYMA laser, infrared light therapy, red light vs laser, mitochondrial activation, SIRT1 gene expression, longevity biohacking, anti aging skin tech, collagen regeneration, fascia repair, scar healing laser, pigmentation removal light, brain optimization light therapy, neuroplasticity support, circulation enhancement, human performance recovery, functional medicine tools, Dave Asprey biohacking

Resources:
• LYMA Website (Use Code ‘DAVE10’ For A Discount: https://lyma.life/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
• 0:00 — LYMA Laser Origin
• 1:20 — Dave’s Early Light Experiments
• 5:15 — Laser vs LED
• 10:54 — Safety and Diffusion Lens
• 16:37 — 808nm and the Brain
• 19:36 — Intimate Performance Effects
• 26:03 — Knee Before and After
• 29:25 — Vampire Bat and Veins
• 37:36 — 6x SIRT1 Activation
• 42:42 — Mitochondrial Signaling
• 45:04 — Veins and Pigmentation
• 52:14 — Scar Recovery
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