Extend Podcast with Darshan Shah, MD

If you care about longevity, you have probably seen the same pattern over and over again. A new peptide, supplement, biological age test, off-label drug, or protocol starts gaining attention, and suddenly it sounds like the missing piece everyone should be using. The hard part is not wanting to be proactive. The hard part is knowing which claims have real evidence behind them, which ones are still early signals, and which ones may carry risks no one is measuring carefully enough.
In this episode, I sit down with Dr. Matt Kaeberlein to talk about how to think about longevity when the answer is rarely a simple yes or no. This conversation helps separate excitement from certainty, and shows why the real question is not only whether something might work, but whether the evidence, safety data, product quality, and risk-reward equation are strong enough to act on.
Dr. Matt Kaeberlein is a scientist in the biology of aging and one of the most respected voices bringing scientific discipline to the longevity conversation. He has been involved with the Interventions Testing Program, which rigorously tests aging interventions in mice, and is one of the leaders behind the Dog Aging Project, a large-scale study looking at aging, health, and longevity in companion dogs. His work sits at the intersection of curiosity and caution, which makes him the right person to talk about what is promising, what is overhyped, and what still needs better evidence.
What's Discussed:
(03:24) Why longevity marketing can move faster than the science.
(06:31) The risk-reward question most people skip before trying a new therapy.
(09:39) Why years of peptide use does not automatically mean safety is proven.
(20:00) The "research use only" peptide problem and why product quality matters.
(34:51) How the Interventions Testing Program separates stronger longevity signals from noise.
(38:39) Why rapamycin changed the field, and why some popular interventions failed to replicate.
(58:43) What the Dog Aging Project may teach us about rapamycin, healthspan, and human aging.
Listen to this episode of Extend to understand how to evaluate longevity claims with more clarity. You will hear what deserves excitement, what deserves caution, and what to ask before turning the next promising intervention into your personal health protocol.
Thank You to Our Sponsors:
Timeline: Timeline powered by Mitopure just dropped the price. Check it out at timeline.com/drshah and get an additional 20% off your first month with code DRSHAH. 
IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at im8health.com/discount/DRSHAH. 
 
Learn More About Dr. Darshan Shah:
Website: drshah.com 
Clinic: next-health.com 
Instagram: darshanshahmd
 
Learn More About Dr. Matt Kaeberlein & the Dog Aging Project:
Website: dogagingproject.org/ 
Instagram: @mkaeberlein

A lot of women are taught to think about hormones only when something becomes impossible to ignore. Painful periods. Birth control decisions. Fertility anxiety. Postpartum changes. Perimenopause symptoms. Menopause. But what if those are not separate conversations? What if the body has been giving clues for years before the symptoms become loud enough to finally get attention?
In this episode, I sit down with Dr. Jila Senemar to look at women's hormone health through a much wider lens. We talk about why the ovary should not be seen only as a reproductive organ, why the hormone conversation needs to start before menopause, and what women may be missing when birth control, AMH, perimenopause, and hormone replacement are treated like separate decisions instead of one connected health story.
Dr. Jila Senemar is an OB-GYN and women's health physician who has spent years caring for women through cycle symptoms, contraception decisions, fertility questions, perimenopause, menopause, and hormone therapy. Her work brings together conventional women's health with a more proactive view of ovarian health, hormone longevity, gut health, bone health, and the full journey women move through over time.
What's Discussed:
(1:02:06) Why women's hormone health should be discussed before menopause.
(1:15:55) How AMH can become a women's health marker before fertility panic begins.
(1:20:50) Why birth control should not be the automatic answer for every cycle issue.
(1:22:07) What changed with lower-dose birth control options.
(1:24:55) How hormonal and non-hormonal IUDs fit into the conversation.
(1:27:36) Why perimenopause may need a different hormone strategy than standard birth control.
(1:31:34) Why hormone therapy should not ignore bone health, gut health, inflammation, and estrogen metabolism.
Listen to this episode of Extend to understand why women's hormones should not be treated like separate stages, and why the earlier clues from the ovary, cycle, gut, bones, and symptoms may matter more than most women are told.
Thank You to Our Sponsors:
Next Health: Your destination for cutting-edge health optimization, from IV therapy to hormone balancing. Explore at next-health.com/
Pendulum: You can go to pendulumlife.com and use my code EXTEND for 20% off your first membership order.
 
Learn More About Dr. Darshan Shah:
Website: drshah.com
Clinic: next-health.com
Instagram: darshanshahmd  
Learn More About Dr. Jila Senemar:
Website: jilamd.com/
Instagram: @drjilasenemar

When a couple is trying to get pregnant and it is not happening, the conversation can become very intense very quickly. Suddenly, you are hearing about IVF, egg freezing, AMH, sperm count, hormones, age, cost, and timing. But before the conversation jumps straight to the next procedure or the next number to panic over, there may be a deeper question worth asking: What is fertility trying to tell us about the health of the mother, the father, and the future child?
In this episode of Extend, I sit down with Dr. Labib Ghulmiyyah to talk about fertility and pregnancy through a much bigger lens. This conversation looks at infertility not as a failure, but as information. It helps explain why fertility struggles, sperm health, ovarian reserve, placental function, and pregnancy complications can all give clues about metabolic health, inflammation, cardiovascular health, hormones, sleep, stress, toxins, and long-term risk.
Dr. Labib Ghulmiyyah is an OB-GYN and residency director at Broward Health who brings together reproductive medicine, pregnancy care, longevity, and functional health. That combination matters because fertility is often treated like a separate category, when in reality, it is connected to the whole body. His approach helps couples think beyond "How do we get pregnant?" and start asking what their reproductive health may be revealing before, during, and after pregnancy.
What's Discussed:
(02:30) Why health optimization should happen before or alongside IVF.
(04:55) How long couples may need to optimize health before fertility treatment.
(07:17) Why the placenta may be one of the most overlooked biomarkers in pregnancy.
(10:40) Why pregnancy complications should be debriefed after delivery.
(18:40) Why the father's health matters far more than sperm count.
(26:15) How testosterone therapy can affect sperm production.
(41:29) Why low AMH does not automatically mean you cannot get pregnant.
Listen to this episode of Extend to understand why fertility is not only about having a baby. It may be one of the earliest windows into your health, your partner's health, and the health of the next generation.
Thank You to Our Sponsor:
FunctionHealth: Learn more and join using my link. Visit functionhealth.com/drshah and use gift code DRSHAH25 for a $25 credit toward your membership. 
Learn More About Dr. Darshan Shah:
Website: drshah.com

Clinic: next-health.com

Instagram: @darshanshahmd
Learn More About Dr. Labib Ghulmiyyah: 
Website: drlabib.com  
Instagram: drlabibghulmiyyah

Your body is constantly repairing, renewing, and rebuilding itself. Hundreds of millions of cells are replaced every few months, which sounds incredible until you ask the question most people skip: if the body is designed to heal, why do so many people still feel tired, foggy, inflamed, slow to recover, or like something is off even when they are doing so many of the "right" things?
In this episode of Extend, I sit down with Justin Roethlingshoefer to bring that question back to the cell. Justin explains why healing is not just about what your body is trying to do, but the environment your cells are trying to do it in. If that environment is missing oxygen, overloaded with toxins, or depleted of nutrients, your body may be creating new cells without giving them the conditions they need to thrive.
Justin Roethlingshoefer is the creator of OWN IT, a coaching platform and app built to help people take ownership of their health through HRV, VO2 max, sleep quality, cellular testing, personalized rhythms, and practical behaviour change. His work helps people cut through the noise of the wellness space and understand what their body actually needs at the cellular level, which is what makes him the right person to explain why feeling better may require more than another supplement, device, or protocol.
What's Discussed:
(03:46) Why your body's ability to repair and renew starts at the cellular level.
(07:59) The three things your cells cannot live without.
(08:36) Why the environment your new cells enter can affect how well they thrive.
(12:33) How VO2 max reflects oxygen efficiency at the cellular level.
(25:37) Why sleep quality matters for cellular detoxification.
(34:30) Why standard blood work may not explain why you still feel off.
(44:24) Why good habits can fall apart inside disordered rhythms.
Listen to this episode of Extend to understand why your body may be trying to heal, why it may still feel like something is not working, and what your cells may need before your next supplement, wearable, protocol, or health habit can actually make the difference you are looking for.
Free resources: 
Quality sleep is the most underestimated longevity accelerator. Download this sleep optimization workbook to transform sleep into a powerful longevity practice: https://www.drshah.com/sleep
Thank You to Our Sponsor:
Next Health Longevity Summit: Head to next-health.com/summit to secure your spot at the first ever Next Health Logevity Summit in Nashville on 9/12.
Momentous:  Head to livemomentous.com/fiber and use code DRSHAH for up to 35% off your first order. 
Learn More About Dr. Darshan Shah:
Website: drshah.com

Clinic: next-health.com

Instagram: @darshanshahmd
Learn More About Justin Roethlingshoefer:
Website: ownitcoaching.com

Holy Health Website: holyhealthbook.com

Instagram: @JustinRoeth

A lot of people are trying to do the right things. They are learning more, tracking their health, working on their stress, trying to be more present, and using the tools they have been told should help. But if the advice is available, the science is clearer than ever, and the tools are right in front of us, why do so many people still feel overwhelmed, burned out, disconnected, or unable to make those changes stick?
In this episode of Extend, I sit down with Dr. Dave Rabin to talk about one of the biggest missing pieces in how we understand stress, healing, and what it actually takes to feel better in the modern world. We get into the questions so many people are quietly carrying: why being human feels harder than it should, why knowing what to do does not always mean your body can follow through, and what it may take to finally turn information into something your body can actually use.
What's Discussed:

(04:28) What Dr. Rabin realized Western medicine left out of his training.
(07:01) Why trauma may be understood differently when viewed through the lens of learning.
(13:42) What parents need to know about screens, discomfort, and regulation.
(21:54) Why stillness is so difficult for many people today.
(27:44) How productivity became tied to worth, and what the body loses when recovery is ignored.
(33:25) Why emotional wounds can be harder to address when they are invisible.
(45:47) Why connection and community may matter more to longevity than many people realize.
Next Health Longevity Summit: Head to next-health.com/summit to secure your spot at the first ever Next Health Logevity Summit in Nashville on 9/12.
Thank You to Our Sponsors:
Timeline: Timeline powered by Mitopure just dropped the price. Check it out at timeline.com/drshah and get an additional 20% off your first month with code DRSHAH.
IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at im8health.com/discount/DRSHAH
Learn more about Dr. Darshan Shah:
Website: drshah.com

Clinic: next-health.com
Instagram: darshanshahmd 
Learn more about Dr. Dave Rabin:
Website: drdave.io

Instagram: @drdavidrabin

The Board of Medicine: boardofmedicine.org

The Psychedelic Report podcast:  podcast/the-psychedelic-report/
Dr. Rabin's new book: ASimpleGuideToBeingAlive.com