PodcastsHealth & WellnessExtend Podcast with Darshan Shah, MD

Extend Podcast with Darshan Shah, MD

Darshan Shah, MD
Extend Podcast with Darshan Shah, MD
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172 episodes

  • Extend Podcast with Darshan Shah, MD

    171. Dr. Kristen Holmes: The Sleep Debt Problem Affecting Your Brain, Mood, and Relationships

    09/06/2026 | 59 mins.
    Sleep debt is usually treated like a personal problem. You sleep less, feel tired, and try to catch up later. But Dr. Kristen Holmes explains why that belief is too small. When your body is missing the sleep it actually needs, it can affect your mental control, emotional regulation, leadership, and even how safe the people around you feel in your presence.
    In this episode of Extend, I sit down with Dr. Kristen Holmes to talk about recovery in a way that goes far beyond "just sleep more." We get into why sleep debt is the gap between what your body needs and what you actually got, why a good night of sleep starts the moment you wake up, and how morning light, sleep consistency, bright days, dark nights, meal timing, stress reframing, breathwork, and outdoor time all shape how well your body restores.
    Dr. Kristen Holmes is a human performance and recovery expert at WHOOP and the author of Aligned: The Data-driven Guide to Performance, Recovery, and Human Potential. Her work connects physiology and psychology to help people understand how sleep, circadian rhythm, stress, movement, mindset, and nervous system regulation influence performance, health, leadership, and long-term resilience.
    What's Discussed:
    (02:27) Why sleep debt is not just about how many hours you missed.
    (03:45) How 45 minutes of sleep debt can reduce mental control the next day.
    (05:31) Why your sleep debt can affect how safe people feel around you.
    (08:08) What sleep quality really means beyond just being asleep.
    (10:33) Why better sleep starts the moment you wake up.
    (14:10) How morning light helps set the clocks in your body.
    (19:16) Why melatonin matters for more than falling asleep.
    (22:01) How bright days, dark nights, breathing, and outdoor time support recovery.
    Listen to this episode of Extend to understand why recovery is not just something you do at night, and how fixing sleep debt can help you think clearer, regulate better, lead better, and show up more fully for the people around you.
    Thank You to Our Sponsors: 
    Momentous: Head to livemomentous.com/fiber and use code DRSHAH for up to 35% off your first order. 
    IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at im8health.com/discount/DRSHAH
     
    Learn more about Dr. Darshan Shah:
    Website: drshah.com
    Clinic: next-health.com
    Instagram: darshanshahmd 
     
    Learn more about Dr. Kristen Holmes
    Instagram: @drkristenholmes
    LinkedIn: linkedin.com/in/kristen-holmes
  • Extend Podcast with Darshan Shah, MD

    170. Dr. Sonya Jensen: The Hormone-Trauma Connection: Why Midlife Symptoms Are Not Just Physical

    04/06/2026 | 57 mins.
    Hormone symptoms are usually treated like a problem with levels. Progesterone is low. Estrogen is shifting. Cortisol is high. Testosterone is dropping. So the conversation often becomes about what to replace, what to supplement, or what protocol to follow. But there is a deeper layer that rarely gets brought into the room: the body is also responding to the stress, grief, resentment, trauma, people-pleasing, perfectionism, and survival patterns it has been carrying for years.
    In this episode of Extend, I sit down with Dr. Sonya Jensen to talk about the connection between mental health and hormonal health. We get into why anxiety can suddenly feel louder in perimenopause, why rage may be years of suppressed resentment asking to be expressed, why grief is not always about losing a person, and why some women still feel stuck even after doing the nutrition, supplements, herbs, or hormone therapy. The aha moment here is that hormones may not be creating a brand-new problem. They may be revealing what the body has been trying to manage in silence.
    Dr. Sonya Jensen is a naturopathic physician, international speaker, author of Heal Your Hormones, Reclaim Yourself, and founder of the HER Method and HER Community. Her work brings together naturopathic medicine, hormone therapy, herbs, nutrition, trauma-informed healing, ancestral healing, longevity medicine, and nervous system support to help women understand the emotional and generational patterns behind hormonal imbalance.
    What's Discussed:
    (02:11) Why hormone imbalance is not only a chemistry issue.
    (03:11) Why women can still feel stuck after doing "all the right things."
    (05:45) How shifting hormones can reveal emotions that were easier to manage before.
    (06:32) Why anxiety can become the symptom women finally cannot ignore.
    (09:09) How stress can show up as isolation, tension, gut issues, and insomnia.
    (13:03) Why perimenopause rage may be suppressed resentment coming up.
    (15:07) How grief in midlife can be tied to identity, motherhood, aging, and transition.
    (30:32) Why hormone therapy can help, but it cannot replace the deeper emotional work.
    Listen to this episode of Extend to understand how hormones, stress, trauma, grief, and the nervous system are connected, and why healing may require looking at the patterns the body has been holding long before symptoms showed up.
    Thank You to Our Sponsors:
    Function Health: Learn more and join using my link. Visit functionhealth.com/drshah and use gift code DRSHAH25 for a $25 credit toward your membership. 
    Learn more about Dr. Darshan Shah:
    Website: drshah.com
    Clinic: next-health.com
    Instagram: darshanshahmd 
    Learn more about Dr. Sonya Jensen: 
    Book - Heal Your Hormones, Reclaim Yourself: healyourhormonesbook.com 
    Website: drsonyajensen.com 
    Instagram: @drsonyajensen
  • Extend Podcast with Darshan Shah, MD

    169. Natalie Lefevre: How to Find the Toxins Blocking Your Body's Ability to Heal

    02/06/2026 | 46 mins.
    You can do the supplements, the IVs, the sauna, the clean eating, and the wellness routine, but if your body is still being exposed to toxins every day, you may be cleaning up a mess while the tap is still running. That is what makes toxic load so frustrating. It can hide in your water, food, air, dental work, travel habits, mold exposure, heavy metals, PFAS, pesticides, microplastics, and even the products you use daily, while standard labs never show the full picture.
    In this episode of Extend, I sit down with Natalie Lefevre to talk about how to outsmart toxins by testing first, removing what is actually there, and choosing the right protocol instead of guessing your way through another cleanse. We get into the rare labs and diagnostics that can reveal hidden toxic load, why not all toxin tests or blood cleanse methods work the same way, how biological dentistry can uncover inflammation that regular dental X-rays miss, and why detox has to become a lifestyle if you want your body to actually heal instead of constantly cleaning up the same exposures. 
    Natalie Lefevre is a Vitality Expert, Detox Architect, and the visionary behind Purify, the first next-generation full-body blood cleanse protocol focused on identifying and removing toxins at the root. After recovering from a near-fatal health crisis linked to environmental toxin exposure, she dedicated her work to advanced rare labs, heavy metals, blood filtration methods, inflammation pathways, cellular function, and precision-based detox strategies, making her one of the most forward-thinking voices in root-cause toxin testing and detoxification.
     
    What's Discussed:
    (01:59) How standard medicine missed Natalie's near-fatal toxic exposure.
    (05:02) Why we are living in the "red zone," not the blue zone.
    (06:30) The hidden toxins most people never test for.
    (11:58) How old dental work can quietly drive inflammation.
    (15:19) Why your genetics can change how your body handles toxins.
    (17:41) The detox mistake people make with saunas and binders.
    (30:43) Why not all blood cleanse protocols remove the same toxins.
    Thank You to Our Sponsors:
    IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at im8health.com/discount/DRSHAH. 
    Timeline: Timeline powered by Mitopure just dropped the price. Check it out at timeline.com/drshah and get an additional 20% off your first month with code DRSHAH.
    Learn more about Dr. Darshan Shah:
    Website: drshah.com
    Clinic: next-health.com
    Instagram: darshanshahmd 
    Learn more about Natalie Lefevre: 
    Instagram: @island_natalie 
    Website: natalielefevre.com/
  • Extend Podcast with Darshan Shah, MD

    168. Peter Crone: Why You Can't Access True Vitality Until You Free Your Mind

    28/05/2026 | 55 mins.
    When we talk about health, longevity, and performance, the conversation often starts with the body. We look at biomarkers, sleep, nutrition, exercise, recovery, and protocols, hoping that if we get enough of the physical pieces right, we will finally feel better, stronger, and more alive. Yet there is another layer that can quietly shape everything from the way we handle stress to the way we heal, lead, love, perform, and experience our own potential.
    In this episode of Extend, I sit down with Peter Crone to explore why true vitality is not only about what is happening in the body, but also about the subconscious stories shaping the mind. We get into the patterns of inadequacy, insecurity, and scarcity, how they can keep the nervous system in survival, why health is not simply the absence of disease, and how the narratives we live inside can affect our physiology, relationships, performance, and ability to feel free. This conversation matters because it challenges the idea that physical optimization alone is enough when the mind is still operating from old constraints.
    Peter Crone is a renowned thought leader in human awakening and potential who helps people dissolve the subconscious constraints shaping their behaviour, health, relationships, and performance. As a transformation coach, writer, speaker, and Ayurvedic practitioner, he has become one of the most trusted voices helping elite athletes, CEOs, and people from all walks of life move beyond survival patterns and access greater freedom, clarity, and ease.
     
    What's Discussed:
    (01:42) How Peter's early life shaped his understanding of survival, isolation, and belonging.
    (03:53) Why true vitality starts with freeing the mind.
    (07:28) The three patterns that keep people in survival: inadequacy, insecurity, and scarcity.
    (09:40) Why modern healthcare often focuses on disease management instead of true health.
    (10:50) Why health is not simply the absence of disease.
    (14:15) How unconscious stories can quietly drive your life.
    (18:44) Why some people do not want life to end, but want an old story to end.
    (46:09) Why self-improvement can still keep people inside the same limited identity.
    Listen now and learn why the story you keep living in may be one of the biggest factors shaping your health, vitality, relationships, and what you believe is possible for your life.
     
    Thank You to Our Sponsors: 
    Function Health: Learn more and join using my link. Visit functionhealth.com/drshah and use gift code DRSHAH25 for a $25 credit toward your membership. 
     
    Learn more about Dr. Darshan Shah:
    Website: drshah.com
    Clinic: next-health.com
    Instagram: darshanshahmd 
     
    Learn more about Peter Crone:
    Website: petercrone.com 
    Linktree: linktr.ee/petercrone
  • Extend Podcast with Darshan Shah, MD

    167. Dr. Amie Hornaman: The Thyropause Problem: Why So Many Women Feel Off in Midlife Despite "Normal" Labs

    26/05/2026 | 55 mins.
    Have you entered midlife and started gaining weight, feeling exhausted, waking up foggy, losing motivation, or noticing your mood shift while your labs keep coming back "normal"? For a lot of women over 40, that answer does not bring relief because they still feel off, and this episode explains why thyropause, the midlife decline in thyroid function, is so often missed, dismissed, or mistaken for aging, burnout, depression, or menopause.
    We dive deeper into this in the Extend Podcast with Dr. Darshan Shah with Dr. Amie Hornaman. We break down why TSH alone is not enough, how thyropause overlaps with perimenopause, menopause, and andropause, and why the real fix starts with a full thyroid panel, proper T4-to-T3 conversion, and a personalized plan built around optimal function instead of "normal" ranges.
    Dr. Amie Hornaman, also known as The Thyroid Fixer, is the founder of the Advanced Thyroid and Hormone Clinic and host of The Thyroid Fixer Podcast. After being misdiagnosed six times herself, she built an international telehealth practice focused on thyroid and hormone optimization. With her clinical experience, book, supplement line, and features in Forbes Health, CBS News, and Fox News, she is one of the most credible voices on why thyroid dysfunction is missed and how to properly address it.
    What's discussed
    (1:16) Why Dr. Amie was told her labs were normal despite clear thyroid symptoms.
    (3:05) The symptoms people often miss, from weight gain and fatigue to hair loss and brain fog.
    (5:33) How thyroid dysfunction can look like ADD, early Alzheimer's, anxiety, or depression.
    (6:55) What thyropause is and why it often overlaps with perimenopause, menopause, and andropause.
    (9:55) Why TSH alone is not enough and what a full thyroid panel should include.
    (13:12) How T4 converts into active T3 and why reverse T3 can block thyroid function.
    (22:09) The connection between low thyroid function, chronic disease risk, and immune function.
    (41:02) Why GLP-1s may not work if thyroid and hormones are not optimized first.
    Listen to this episode of Extend with Dr. Darshan Shah on Apple Podcasts or Spotify to understand why "normal" labs may not be the full answer, what thyroid markers actually matter, and how optimizing thyroid function can change your energy, metabolism, mood, hormones, and long-term health.
    Thank You to Our Sponsors:
    Momentous: Head to livemomentous.com/fiber and use code DRSHAH for up to 35% off your first order. 
    Learn more about Dr. Darshan Shah:
    Website: drshah.com
    Clinic: next-health.com
    Instagram: darshanshahmd 
     
    Learn more about Dr. Amie Hornaman:   
    Website: dramie.com 
    The Thyroid Fix book: thyroidfixbook.com 
    Instagram: @dramiehornaman 
    Facebook: www.facebook.com/groups/dramie 
    YouTube: youtube.com/dramiehornaman 
    TikTok: @dramiehornaman 
    7-day Thyroid Healing Kickstart: fixyourthyroid.com/7daykickstarter
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About Extend Podcast with Darshan Shah, MD
Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.
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