Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

• p-Tau 217: The Breakthrough Biomarker Revolutionizing Early Alzheimer’s Detection

  Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify pathology associated with Alzheimer's disease before symptoms even appear. What’s even more fascinating is how these same tools are revealing neuroinflammation caused by infections, including COVID, Lyme disease, and mold exposure—issues that are incredibly relevant in functional medicine today. The assays Dr. Frykman and his team have developed, and continue to research, are transforming the way we think about diagnosing and addressing neurodegeneration. We’re talking about a potential game-changer that allows us to intervene earlier, reverse damage, and ultimately improve the trajectory of these conditions. This is an extraordinary time in science and medicine, and the work we’re discussing today is at the forefront of it all. Don’t miss out on how this could reshape your practice. ~DrKF Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources. GUEST DETAILS Dr. Hans Frykman, MD PhD FRCPC [email protected] Hans Frykman MD, Ph.D., FRCPC is the founder, CEO, and medical director of BC Neuroimmunology Lab located in the UBC hospital on the University of BC campus in Vancouver BC. He is the medical director for Lykke Lab a genetics laboratory also on the University of BC campus. Also, he is the CSO for Neurocode Lab Inc. in Bellingham WA, a high-complexity, specialty lab focused on neuroimmunology and biomarkers in neurodegeneration. Dr. Frykman has a clinical faculty position at the University of British Columbia, Faculty of Medicine, Division of Neurology. THANK YOU TO OUR SPONSORS DIAMOND DUTCH: https://dutchtest.com/for-providers Biotics Research: https://www.bioticsresearch.com/ GOLD TimeLine Nutrition: https://tinyurl.com/bdzx2xms Vibrant Wellness: https://www.vibrant-wellness.com/ EXCLUSIVE OFFERS FROM OUR SPONSORS OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA Try Qualia NAD+ for up to 50% off! Visit http://qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase! Why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/2b5benmd Want more? CONNECT WITH DrKF Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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  1:07:49
• Cutting-Edge Metabolomic Testing for IBS, Longevity, and Metabolic Health

  We’re witnessing an exciting shift in how we understand gut health and disease—and it’s all thanks to the powerful metabolites produced by the microbiome, like short-chain fatty acids (SCFAs) and secondary bile acids. In today’s episode, Dr. Tom Fabian shares groundbreaking insights into how these postbiotics influence intestinal barrier integrity, immune balance, and even muscle regeneration. These compounds are also connected to key processes like glucose metabolism and healthy aging. What’s truly fascinating is how this science is opening up new frontiers in treating IBS, metabolic conditions, and chronic gut issues. With the upcoming launch of Diagnostic Solution Laboratories’ StoolOMX test, an add-on to the GI-MAP, we now have a tool to measure these metabolites in clinical practice, making personalized and effective treatments more attainable. This is a pivotal moment in functional medicine that you don’t want to miss. ~DrKF FOLLOW ALONG WITH THE CONVERSATION! Get the Updated GI-MAP® Guide with StoolOMX™ Insights! The new GI-MAP® Guide now includes StoolOMX™ insights on bile acids and short-chain fatty acids, enhancing your understanding of IBS, IBD, and gut motility. Refine treatment strategies and optimize patient care with this essential resource. Download now! https://tinyurl.com/5ehysjp7 Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources. GUEST DETAILS Thomas Fabian, PhD, CNTP Email: [email protected] Dr. Fabian is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. As a translational scientist, his primary focus is on the clinical application of microbiome research in the integrative and functional medicine space. He received his PhD in molecular biology from the University of Colorado, Boulder, and has worked as a biomedical researcher in the biotechnology industry, and more recently, as a consultant in the microbiome testing field. Currently, Dr. Fabian serves a consultant and science advisor with Diagnostic Solutions Laboratory, and he is also a Science Advisory Board member with Designs for Health. In addition, he is certified as a Nutrition Therapy Practitioner by the Nutrition Therapy Institute in Denver. THANKS TO OUR SPONSOR Diagnostic Solutions Laboratory: https://www.diagnosticsolutionslab.com/ Phone: 877-485-5336 CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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  1:01:56
• A Fresh Take on Exposomics: Resiliency Factors That Offset Environmental Risks

  It’s very difficult (often impossible) to completely avoid many of the environmental toxins that can cause harm - like air pollution and forever chemicals that contaminate our water and food supply. But Drs. Bob and Rosalind Wright at Mount Sinai have a hopeful solution to this dilemma. They are pioneering the study of “resiliency factors,” not just “risk factors,” that can offset the risks of harmful exposures. It’s a fresh and welcome take on exposomics that I am very excited to share with you. For instance - did you know that omega-3 intake during pregnancy can protect against the development of asthma in the child, even if the child is exposed to known risk factors for asthma? Or that positive relationships (ones that create a sensitive, positive, caregiving environment) have been shown to potentially mitigate the effects of environmental toxins? As a practitioner, I am always looking to empower patients with real solutions to the health challenges we inevitably face and I hope you enjoy this conversation as much as I did. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Dr. Rosalind J. Wright, MD, MPH and Robert O. Wright, MD, MPH Icahn School of Medicine at Mount Sinai https://icahn.mssm.edu/ Dr. O. Robert Wright is the Ethel H. Wise Chair of Environmental Medicine at Mount Sinai and co-founder of the Institute for Exposomic Research. His research links environmental exposures, like those tracked in the PROGRESS cohort, with the developmental origins of diseases. Dr. Rosalind J. Wright is Dean for Public Health at Icahn School of Medicine and Co-Director of the Institute for Climate Change, Environmental Health, and Exposomics. A pioneer in environmental health, she studies how early-life exposures influence chronic diseases and has been NIH-funded for over 23 years. She also mentors the next generation of clinical scientists. THANKS TO OUR SPONSORS DIAMOND DUTCH: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD OneSkin: http://oneskin.co/DRKARA TimeLine Nutrition: https://tinyurl.com/bdzx2xms Vibrant Wellness: https://www.vibrant-wellness.com/ EXCLUSIVE OFFERS FROM OUR SPONSORS Try QUALIA NAD+ for up to 50% off! Visit https://www.qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase. OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA CONNECT with DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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  1:09:32
• This GLP-1-Supporting Probiotic Is A Constant In Our Longevity Stack

  Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause. As someone who's deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Colleen Cutcliffe, PhD, Co-Founder and CEO of Pendulum Therapeutics Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 25 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to starting Pendulum, Colleen was the senior manager of biology at Pacific Biosciences and a scientist at Elan Pharmaceuticals. Colleen completed her postdoctoral studies at Northwestern’s Children’s Memorial Hospital. Colleen received her Ph.D. in Biochemistry and Molecular Biology from Johns Hopkins University and her B.A. in Biochemistry from Wellesley College. THANKS TO OUR SPONSOR Pendulum: https://tinyurl.com/hzbxh75f EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS Healthcare providers - Create a healthcare account with Pendulum to unlock wholesale pricing and get $50 off your first wholesale order with code WSKARA50 at https://tinyurl.com/hzbxh75f Not a practitioner but ready to try Pendulum probiotics for yourself? Take 20% off your first membership order with code KARA20 at checkout. https://tinyurl.com/2tjp3jb4 CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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  54:11
• Healing Depression Project: Providing Hope For Treatment-Resistant Patients

  For many struggling with depression, the message they often hear from traditional care is "just live with it" or "there’s nothing more we can do." In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli from the Healing Depression Project - a groundbreaking residential treatment and research program. Dr. Stein, a functional psychiatrist, and Silvia, who’s personally battled chronic depression, are offering a fresh approach to treatment-resistant depression. Their in-residence program, launching in March, takes a whole-person approach—integrating nutrition, lifestyle changes, trauma healing, and community support. And with research built into the program, they’re not just helping patients; they’re also paving the way to make this approach more accessible for everyone. If you’re ready to rethink depression treatment, this episode is for you. ~DrKF Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources. GUEST DETAILS Dr. Achina Stein DO, IFMCP and Silvia Covelli, creator of Healing Depression Project Website: https://www.healingdepressionproject.com/ Schedule a free call with Silvia or Dr. Stein at: https://tinyurl.com/2z3dxtv7 NOW ACCEPTING APPLICATIONS The team at Healing Depression Project is thrilled to announce an upcoming 45-Day Depression Recovery Program starting on March, 2025. The program includes a 30-day in-person retreat at a deluxe and serene ranch in Austin, TX, followed by a 15-day at-home integration phase, ensuring sustainable improvement. Scholarship Opportunities Available: Participants who are invited to apply can also apply for a scholarship program. If a scholarship is awarded, it can cover up to 80% of the total investment. Schedule a call for details: https://tinyurl.com/2z3dxtv7 THANK YOU TO OUR SPONSORS DIAMOND DUTCH: https://dutchtest.com/for-providers Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD OneSkin: http://oneskin.co/DRKARA TimeLine Nutrition: https://tinyurl.com/bdzx2xms Vibrant Wellness: https://www.vibrant-wellness.com/ THANK YOU TO OUR SPONSORS DIAMOND DUTCH: https://tinyurl.com/4anbz7b3 Biotics Research: https://www.bioticsresearch.com/ Integrative Therapeutics: https://tinyurl.com/4emwj48z GOLD OneSkin: http://oneskin.co/DRKARA TimeLine Nutrition: https://tinyurl.com/bdzx2xms Vibrant Wellness: https://www.vibrant-wellness.com/ EXCLUSIVE OFFERS FROM OUR SPONSORS Try QUALIA NAD+ for up to 50% off! Visit https://www.qualialife.com/kara15 and use code KARA15 at checkout for an additional 15% off your entire purchase. OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA Want more? CONNECT WITH DrKF Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You Group Program: https://tinyurl.com/4hvusavw Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

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  1:11:12

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About Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics