Despite the market success of GLP-1 agonists to treat obesity, many patients suffer side effects such as nausea, diarrhea, and vomiting. These medicines also cause significant loss of muscle mass. And when someone discontinues use, they often regain the weight they lost. Skye Bioscience is developing nimacimab, an experimental therapy that has the potential to induce weight loss by inhibiting the CB1 receptor. Because of its different target, it may be able to be used in conjunction with GLP-1 agonists and lower the dose of those drugs to make them more tolerable, or combined with other therapeutic approaches. We spoke to Punit Dhillon, president and CEO of Skye Bioscience, about CB1 as a target for treating obesity, its experimental therapy nimacimab, and the potential to combine it with GLP-1 agonists and other therapeutic approaches.
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A Novel Approach to Treating Chronic Low Back Pain
Many companies are seeking to develop non-opioid treatments for pain, but Persica Pharmaceuticals may be taking a surprising approach for chronic low-back pain. The company’s lead experimental therapy for the condition is an antibiotic. That may sound odd, but it turns out that about half of chronic low back pain cases are due to bacterial infections that occur after herniation of the spinal disc or injury. We spoke to Steve Ruston, CEO of Persica Pharmaceuticals, about the need for new approaches to chronic low back pain, the company’s experimental targeted intradiscal antibiotic injections, and the need to educate physicians about the role infection can play in the condition.
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A Biologic Designed to Treat Acute Exacerbations of Asthma and COPD
Though there are plenty of therapeutic alternatives for asthma and chronic obstructive pulmonary disease, or COPD, there are no approved biologics for treating acute exacerbations of these conditions. Connect Biopharma believes that’s an opportunity. It's experimental therapy rademikibart has shown promise treating exacerbations and providing sustained improvements. We spoke to Barry Quart, CEO of Connect Biopharma, about the unmet need the company is seeking to address, how rademikibart works, and Connect’s repositioning as a U.S.-centric company.
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Turbocharging Drug Discovery with Health Data
When Vanderbilt University Medical Center began to consider how big data and precision medicine were going to impact both research and development and clinical care, it struck on the idea of building a large-scale biobank and tying it to its store of millions of electronic health records. That ultimately led to the founding of Nashville Bioscience, a for-profit subsidiary of the medical center. We spoke to Leeland Ekstrom, co-founder and CEO of NashBio, about the company’s data collection methods, the significance of the alliance it's developed with leading biopharmaceutical companies, and how it's enabling a transformation of drug development with data.
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Revolutionizing the Production of Biologics with Algae
Spirulina, also known as blue-green algae, is edible. It can be engineered to cost-effectively produce biologics that can be taken orally. Though people have long sought to do this, Lumen Bioscience has developed platform technology that solved the various challenges is engineering spirulina to produce medicines. We spoke to Brian Finrow, co-founder and CEO of Lumen, about the company’s platform technology, why it makes possible the pursuit of biologics for indications that were previously not practical, and the potential to make these advanced therapies affordable and accessible in parts of the world where people may not have widely enjoyed their benefits.
The Bio Report podcast, hosted by award-winning journalist Daniel Levine, focuses on the intersection of biotechnology with business, science, and policy.
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