No Priors: Artificial Intelligence | Technology | Startups

• How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara

  Bringing new drugs to market is a costly, time-consuming endeavor. On top of that, most medicines fail at some point in the research and development phase. Sarah Guo is joined by Sajith Wickramasekara, co-founder and CEO of Benchling, a company that has not only become the central system of record for biotech R&D, but uses AI agents to assist scientists to help fix this broken system. Sajith details the roadblocks that impede drug development and approval, the “dot com” bust occurring in biotech, and how AI agents and simulation can help scientists experiment faster. Plus, they talk about China’s competitive rise in the pharma space, and the unique challenges of building an interdisciplinary culture that merges the worlds of science and software.  Rebuild biotech for the AI era - Sajith Wickramasekara Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @sajithw | @benchling Chapters: 00:00 – Sajith Wickramasekara Introduction 00:38 – Origin and Mission of Benchling 02:08 – The Drug Development Process 03:49 – Current State of the Biotech industry  08:46 – AI’s Role in Biotech 16:14 – Benchling AI and Its Impact 18:36 – The Future of AI in Biotech  26:28 – Debunking AI Drug Discovery Myths 28:50 – Data’s Role in Biotech 29:35 – The Importance of Tools in Pharma 31:28 – AI’s Impact on Scientific Research 34:55 – Building a Biotech Company 40:18 – Interdisciplinary Collaboration in Biotech  43:06 – Tech and Biotech: Learning from Each Other 48:16 – Conclusion

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• Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy

  Snowflake is moving beyond the data warehouse. Its new Snowflake Intelligence is an agentic platform for every employee, not just data teams. Sarah Guo sits down with Snowflake CEO Sridhar Ramaswamy to discuss his first 18 months at the helm, as well as the massive pivot to make the data giant AI-first. Sridhar talks about Snowflake Intelligence, the company's new AI agent platform, and its implications for enterprise data management. They also explore how Sridhar navigates partnerships with major tech companies, how he fosters a culture of continuous improvement within the organization, and how he envisions Snowflake’s future as an integral data-driven enterprise solution.  Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @Snowflake Chapters: 00:00 – Sridhar Ramaswamy Introduction 00:42 – Snowflake’s Market Adaptation 03:14 – Snowflake’s Evolution and AI Integration 05:44 – Introducing Snowflake Intelligence 09:01 – Snowflake Intelligence User Experience 11:55 – Drawing the Line Between Data, Agent System, and App 13:30 – Leadership and Organizational Changes 16:19 – How Being an Investor, Entrepreneur Informed Sridhar’s Leadership 18:50 – Importance of Product-Market Fit 22:46 – Snowflake’s Strategic Positioning 27:10 – Snowflake’s Partnership Strategy 30:20 – How Sridhar Sees the ROI of AI 35:09 – How AI Changes the Ad Model 38:15 – Why LLMs Still Need Search 42:11 – Conclusion

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• The Best of 2025 (So Far) with Sarah Guo and Elad Gil

  2025 has thus far been a year of great leaps and advances in AI technology. And Sarah and Elad have spoken with some of the most enterprising founders and scientific minds in the field of AI today. So we’re revisiting a few of our favorite conversations on No Priors so far in 2025 – Winston Weinberg (Harvey), Dr. Fei-Fei Li (World Labs), Brendan Foody (Mercor), Dan Hendrycks (Center for AI Safety), Noubar Afeyan (Flagship Pioneering), Brandon McKinzie and Eric Mitchell (OpenAI o3), Isa Fulford (OpenAI), Arvind Jain (Glen), and Dr. Shiv Rao (Abridge).  Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil  Chapters: 00:00 – Episode Introduction 0:21 – Winston Weinberg on Leaning into New Capabilities 02:01 – Dr. Fei-Fei Li on Spatial Intelligence 04:13 – Brendan Foody on AI Disruption in the Workforce 06:10 – Dan Hendrycks on the Geopolitics of Superintelligence 08:06 – Noubar Afeyan on Entrepreneurship   10:38 – Brandon McKinzie and Eric Mitchell on Reasoning Models 12:41 – Isa Fulford on Training Deep Research 13:49 – Arvind Jain on Innovating Enterprise Search 16:21 – Dr. Shiv Rao on AI’s Human Impact 18:58 – Conclusion

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• Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd

  For decades, the developer terminal has remained largely unchanged. But for Warp CEO and co-founder Zach Lloyd, reinventing this core tool is the key to unlocking AI agents for coding, debugging, and automating the entire development process. Zach joins Elad Gil to discuss how seeing this opportunity for innovation led to Warp’s agentic terminal for developers. Zach talks about the phases of software development, from coding by hand to the current "develop by prompt" era, and the coming age of fully automated development. Plus, Zach and Elad explore the deep philosophical questions around intelligence versus consciousness in AI models, and what it would take to believe a computer program is truly aware. Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @zachlloydtweets | @warpdotdev Chapters: 00:00 – Zach Lloyd Introduction 00:32 – AI, Intelligence, and Consciousness 06:55 – What Warp Does 07:38 – Benefits of the Terminal as a Launchpoint  08:27 – Features Driving Warp’s Adoption 09:12 – Zach’s View of the Coding Market 10:27 – Evolution of Coding Development 12:45 – Importance of Senior Engineer Expertise 14:11 – Future of Security and Other Dev Tools 22:22 – Why Zach Focused on the Terminal 23:52 – The Future of the Model Layer  25:36 – What Zach’s Excited About in the AI Dev World 27:18 – Conclusion

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• Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell

  With demand from AI for energy already exploding, our electric grid is facing a crisis. Base Power CEO and co-founder Zach Dell is ready to re-architect its future from the ground up. Zach sits down with Elad Gil to talk about Base Power’s recent $1 billion fundraise from major investors. Zach discusses the role of energy across industries, as well as Base Power's mission to lower electricity costs through vertical integration. Zach and Elad also explore the future of energy, the role of batteries in transforming the grid, and the regulatory challenges facing the energy industry. Plus, Zach pitches why top talent should make their careers in energy generation.   Sign up for new podcasts every week. Email feedback to [email protected] Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @ZachBDell | @basepowerco Chapters: 00:00 – Zach Dell Introduction 00:50 – Base Power’s Vision 02:15 – Base Power’s Products and Services  04:00 – What Drew Zach to Working on Power 05:12 – Base Power’s Founding Team 06:58 – Base Power’s Hiring Needs 08:02 – How Zach Hired an Awesome Founding Team 09:51 – How Do We Meet Energy Demands? 12:58 – How Viable is Nuclear Energy? 17:04 – Global Energy Cost Dynamics 17:41 – Future of AI Training Centers 18:32 – What Will Drive Energy Buildout 20:38 – Drivers of Energy Transmission Cost 22:30 – Regulation and the Energy Industry  23:52 – What Zach is Optimistic About in Energy 24:42 – Cultivating Base Power’s Culture 27:26 – Zach’s Philosophy on Capitalization 30:00 – How Base Power Uses Scale 31:57 – Conclusion

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