Medical News Podcast

• Hearing aids help slow brain aging process in adults with mild cognitive impairment

  Can the use of hearing aids slow down cognitive decline? Find out about this and more in today's PeerDirect Medical News Podcast.

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• The Changing Landscape of Therapy in HER2-Low and Ultralow Breast Cancer (Part 2)

  Dr. Drago and Dr. Traina continue their discussion of breakthrough developments in triple-negative breast cancer treatment, sharing highlights from the promising ASCENT-04 trial results with sacituzumab govitecan plus pembrolizumab in first-line treatment. They also address key clinical challenges around sequencing antibody-drug conjugates and managing interstitial lung disease toxicity.

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• What are the potential health and safety implications for children now that a CDC advisory panel has moved to withdraw the universal birth-dose recommendation for the hepatitis B vaccine in newborns?

  The ACIP voted to replace universal newborn hepatitis B vaccination with shared clinical decision-making for infants of mothers who test negative, a move strongly criticized by major medical and public health groups who warn it could reverse decades of progress in preventing pediatric hepatitis B. A large NEJM trial found that a single dose of HPV vaccine provides protection equivalent to two doses over five years, supporting simplified global vaccination strategies. Real-world evidence from nearly 5,000 patients shows dapagliflozin and empagliflozin deliver similar safety and effectiveness across all forms of heart failure.

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• The Changing Landscape of Therapy in HER2-Low and Ultralow Breast Cancer (Part 1)

  Dr. Tiffany Traina and Dr. Josh Drago discuss the evolving treatment landscape for HER2-low and ultralow breast cancer, highlighting how pivotal trials like Destiny Breast-04 and Destiny Breast-06 have demonstrated significant efficacy improvements with trastuzumab deruxtecan while emphasizing the need to balance its toxicity profile with benefits for individual patients.

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• Updated 2025 Recommendations: Allo-HCT and CAR T-Cell Therapy in CLL (Part 2)

  Drs. Danilov and Coombs review the evolving treatment strategies for CLL, focusing on the use of CAR T-cell therapy and allogeneic stem cell transplant in different disease stages, particularly for patients with relapsed or refractory disease. They emphasize the importance of tailoring treatment to individual patient needs, considering clinical trials, and recognizing challenges.

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