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Dhru Purohit Show

Dhru Purohit
Dhru Purohit Show
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  • Why It’s So Hard to Lose Weight for Women 40+ and How to Optimize Hormones During Perimenopause and Menopause with Dr. Sara Gottfried (Rebroadcast)
    This episode is brought to you by BiOptimizers and Cozy Earth. As women enter their late 30s and beyond, many start experiencing symptoms like insomnia, brain fog, weight gain, and irritability—yet far too often, these changes are brushed off or misdiagnosed. But it doesn’t have to be this way. Today, on The Dhru Purohit Show, we’re bringing back one of our most impactful conversations with Dr. Sara Gottfried—physician, hormone expert, and bestselling author—for a powerful look at what’s really happening in women’s bodies during perimenopause and menopause. Dr. Gottfried breaks down the science behind common symptoms, the key hormone shifts driving them, and the tests every woman should know about. She also shares actionable strategies to help women rebalance their hormones, reclaim their energy, and feel like themselves again—all while laying the foundation for long-term health and vitality. Dr. Sara Gottfried is a Harvard- and MIT-trained physician and bestselling author specializing in precision, integrative, and Functional Medicine. She’s a Clinical Assistant Professor at Thomas Jefferson University and Director of Precision Medicine at the Marcus Institute. Her latest book is The Autoimmune Cure, focused on healing trauma and other triggers behind autoimmune disease. In this episode, Dhru and Dr. Gottfried dive into: The metabolic crisis that women in their 40s go through and the hope that Dr. Gottfried offers on a different way to be and live (00:11) How conventional medicine often dismisses the symptoms that women feel and makes them feel it's a normal part of aging (5:35) The top misconceptions or misunderstandings about the interplay between hormones, including how long before menopause symptoms can start (10:44) Women with high cortisol levels in their 40s had decreased brain volume and memory (16:25) Common symptoms of perimenopause and menopause as they relate to aging: mood swings, depression, insomnia, and loss of libido (17:54) The environmental and lifestyle factors that impact women’s hormones, including stress, ultra-processed foods, and exposure to endocrine disruptors (26:30) The top 3 hormones to balance and correct: cortisol, estrogen, and thyroid (37:50) The importance of testosterone as the most abundant hormone in women’s bodies (41:00) How Dr. Gottfried started her hormonal journey by testing her cortisol and how prioritizing meditation and yoga reduced her stress response (48:17) Dealing with insomnia during perimenopause, when it’s especially critical to prioritize sleep and how progesterone can help (58:50) Testing thyroid levels at least once a year and the connection between thyroid and autoimmune disease (1:12:00) Bringing hormones into harmony by increasing protein, reducing ultra-processed foods, increasing fiber, and eating quality fat (1:17:55) The key to feeling better in menopause is measuring and addressing your glucose levels (1:29:02) What drives belly fat, and the relationship between belly fat and cortisol (1:43:30) Micronutrients, including vitamin D and copper, and how they impact thyroid levels (1:46:36) The role of post-traumatic stress and the use of psychedelics (1:50:06)Helping women over 40 and the importance of healing states of consciousness (2:03:21) Dr. Gottfried’s message of how it doesn’t have to be this way (2:08:44) Also mentioned: Full episode with Dr. Sara Gottfried For more on Dr. Sara Gottfried, follow her on Instagram, Facebook, Twitter, YouTube, and through her Website. This episode is brought to you by Bioptimizers and Cozy Earth. Go to bioptimizers.com/dhru now and enter promo code DHRU10 to get 10% off any order of Sleep Breakthrough and find out this month’s gift with purchase. Right now, get 40% off your Cozy Earth sheets and sleepwear.. Just head over to cozyearth.com/dhru and use code DHRUP. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Big Idea: Struggling with High Blood Pressure and Inflammation? You Might Need to Improve Your Nitric Oxide—Here's How
    This episode is brought to you by Cozy Earth and Maui Nui. Each year, nearly 700,000 lives are lost to cardiovascular disease—and half of those individuals had no warning signs before their event. One major contributing factor? Low levels of nitric oxide, a vital molecule that supports healthy blood flow and keeps blood vessels flexible. The good news is that lifestyle changes—like diet, exercise, and proper supplementation—can naturally boost nitric oxide levels, helping to reduce your risk and support long-term heart health. Today on The Dhru Purohit Show, we’re revisiting one of our most talked-about moments with Dr. Nathan Bryan, all about why nitric oxide is the most underrated molecule for both short- and long-term health. Dhru and Dr. Bryan explore the connection between low nitric oxide levels and major conditions like heart disease, high blood pressure, Alzheimer’s, sexual dysfunction, and metabolic decline. They also dive into the biggest blockers of nitric oxide production, the top foods and lifestyle choices to naturally boost it, signs of deficiency, and so much more. Dr. Nathan Bryan is a leading expert in molecular medicine and nitric oxide research, with over 20 years of groundbreaking work and dozens of global patents. He’s the founder of Nitric Oxide Innovations, a company developing nitric oxide-based therapies to improve health worldwide. In this episode, Dhru and Dr. Bryan dive into: What happens in the body when we don’t produce enough nitric oxide (1:17) The link between nitric oxide and heart health (3:30) How nitric oxide is produced in the body (11:22) Habits that boost nitric oxide production (15:07) How mouthwash inhibits nitric oxide production (17:05) Nasal breathing and nitric oxide production (29:18) The impact of proton pump inhibitors on creating nitric oxide (32:23) Foods to avoid and transitioning to an anti-inflammatory diet (40:16) High blood pressure and its link to nitric oxide (42:17) Final thoughts (44:58) Also mentioned: Full episode with Dr. Nathan Bryan This episode is brought to you by Cozy Earth and Maui Nui. Right now, get 40% off your Cozy Earth sheets and sleepwear. Just head over to cozyearth.com/dhru and use code DHRUP. Right now, Maui Nui Venison is offering my listeners a limited collection of my favorite cuts and products. Just go to mauinuivenison.com/dhru to secure your access now —but hurry, supply is limited! Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Are Parents Getting the Full Story When It Comes to Vaccines? Top Pediatrician Shares the Vaccine Research We Need to Hear with Dr. Joel Warsh
    This episode is brought to you by Bon Charge, Momentous, One Skin, and Branch Basics. It’s difficult to have a balanced conversation about vaccines. Both sides often jump to conclusions, leaving little room for nuanced, open dialogue. Just a few years ago, even sharing a podcast discussing vaccines could result in it being flagged. In this episode, Dr. Joel Gator Warsh joins us for a thoughtful conversation—one that doesn’t push any agenda, but simply aims to share information. Today on The Dhru Purohit Show, Dhru sits down with Dr. Joel “Gator” Warsh for a deep dive into the topic of vaccines. Dr. Gator discusses what the gold standard for vaccine testing should look like and what it truly means to provide informed consent. He addresses common concerns about additives in vaccines and emphasizes that his role is to educate—not to influence or bias—parents in making the best decisions for their children. He also explains why current research is lacking when it comes to understanding the potential long-term health impacts of vaccines, and shares his hopes for more robust studies and open, nuanced conversations moving forward. Dr. Joel Gator Warsh is a Board-Certified Pediatrician based in Los Angeles, California, specializing in parenting, wellness, and integrative medicine.  In 2018, he founded his current practice, Integrative Pediatrics and Medicine, in Studio City.  In this episode, Dhru and Dr. Gator dive into: What does “vaccine placebo” mean, and the differing definitions (00:17) Dr. Gator’s belief in providing information for truly informed consent (3:10) Questions about the ingredients and additives in vaccines (6:30) Why Dr. Gator started asking questions about vaccines (10:05) Why vaccine research typically doesn't use traditional placebo-controlled trials (19:47) The rise in public awareness and the future of vaccine studies (24:53) COVID as a major awakening regarding vaccines and peer reviews of vaccine trials (32:44) The history of polio and the increase in vaccines for various conditions (45:33) How vaccines have turned into a political issue (50:30) Stories from Dr. Gator’s patients, his recommendations, and an alternative schedule for newborns (59:21) Vaccines and concerns about autoimmune diseases and cumulative effects (1:13:20) The need for further research on vaccines and the possible correlation with autism (1:18:39) The measles vaccine: when to get it and debunked studies regarding its correlation to autism (1:34:49) Dr. Gator’s new book and what he hopes it contributes to the vaccine discussion (1:47:09) Does the flu vaccine make a difference (1:50:49) Final thoughts (1:54:47) Also mentioned in this episode: Dr. Gator's new book - Between a Shot and a Hard Place A Deep Dive on the Fraud, Deception, and Misdirection of Big Pharma with Dr. John Abramson For more on Dr. Gator, follow him on Instagram, X/Twitter, Facebook, Pinterest, LinkedIn, or visit his Website. This episode is brought to you by Bon Charge, Momentous, One Skin, and Branch Basics. Right now, Bon Charge is offering my community 15% off; just go to boncharge.com/DHRU and use coupon code DHRU to save 15%. Momentous is having its anniversary sale from now through June 27th. Support your energy, bones, and resilience with The Women’s Three: Iron, Calcium, and Vitamin D3—formulated by experts, made for women. Head to livemomentous.com and use code FORLIFE for 40% off your first subscription. Right now, One Skin is offering my community 15% off; just go to oneskin.co and use coupon code DHRU to save 15% and give your skin the scientifically proven, gentle care it deserves. Right now, Branch Basics is offering 15% off the Premium Starter Kit; just go to branchbasics.com and use coupon code DHRU. Make 2025 your cleanest, healthiest year yet with Branch Basics!   Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • Big Idea: Why Are Seed Oils So Pervasive and The Case For and Against Them
    This episode is brought to you by Momentous, Ollie, and Manukora Honey. Vegetable oils are a hot topic in the wellness world. Some consider them a heart-healthy alternative to saturated fats, while others argue they may be far more harmful to our overall health than once believed. But where did they come from, and how did they become so widely used?  Today on The Dhru Purohit Show, Dhru sits down with Jeff Nobbs to discuss the history of seed oils and how they’ve become ubiquitous in restaurants and ultra-processed foods. He also describes the research limitations and selective reporting that have heavily influenced their recommendation and use. Jeff Nobbs is the cofounder and CEO of Zero Acre Farms, a company replacing harmful vegetable oils with healthier, more sustainable options made through fermentation. With over 15 years of experience in health and nutrition, Jeff has launched several start-ups focused on better ingredients and food access, including the restaurant chain Kitava and the nonprofit HelpKitchen. He’s also served as COO of Perfect Keto and GM at Ebates (now Rakuten). In this episode, Dhru and Jeff dive into: The history of seed oils and how they became so pervasive (04:01) Why trans fats were banned from commercial production (17:26) Observational research and the case for seed oils (21:40) Randomized controlled trials and the case against seed oils (28:21) Biomarkers in people who consume seed oils and observational data on trans fats (33:04) The Minnesota Coronary Experiment (40:32) McDonald’s transition to seed oils (43:15) Final thoughts (44:36) Also mentioned: Full episode with Jeff Nobbs This episode is brought to you by Momentous, Ollie, and Manukora Honey. Support your energy, bones, and resilience with The Women’s Three: Iron, Calcium, and Vitamin D3—formulated by experts, made for women. Head to livemomentous.com and use code DHRU for 35% off your first subscription. Want to give your dog the best in clean eating? Take the online quiz and introduce Ollie to your pet. Right now, Ollie is offering 60% off your first box of meals when you subscribe today! Just head to Ollie.com, use the code DHRU, and you’ll get 60% off your first box of meals in your subscription. Upgrade to the creamiest honey, packed with antioxidants and prebiotics. Just go to manukora.com/dhru to get $25 off the Starter Kit and boost your energy, immunity, and digestive health today! Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
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  • The Best and Worst Habits to Age Well, Avoid Frailty, and Keep a Healthy Weight with Dr. Mary Pardee
    This episode is brought to you by Cozy Earth, Branch Basics, and Fatty15. Aging well isn’t just about looking young on the outside—it’s about building habits that keep our bones strong and our body composition healthy. Today’s guest ranks the top habits that support these goals and help enhance our healthspan. Today on The Dhru Purohit Show, Dhru sits down with Dr. Mary Pardee to rank the best and worst habits for aging well, avoiding frailty, and maintaining a healthy body composition. Dr. Pardee breaks down the staggering statistics on osteoporosis and highlights the importance of a DEXA scan, plus when you should consider getting one. She also shares her insights on longevity-specific testing, including a full lipid panel and coronary CT scan. Finally, Dr. Pardee ranks key lifestyle habits, such as achieving 10,000 steps a day, walking after meals, strength training, and following specific diets. Wondering where GLP-1 medications and hormone replacement therapy fall on the list? Dr. Pardee shares her nuanced take on those, too. Dr. Mary Pardee is a Naturopathic Medical Doctor specializing in preventative medicine and longevity in Los Angeles, California. She has an undergraduate degree in human nutrition and has worked in exercise physiology and performance research for the US government. She holds a doctorate in naturopathic medicine from Bastyr University. Dr. Mary is the founder of modrn med, a medical practice that provides medical and health services to patients via in-person consults as well as telemedicine. Her primary focus is on closing the healthspan-lifespan gap, extending lifespan, and enhancing healthspan.   In this episode, Dhru and Dr. Pardee dive into: The statistics on osteoporosis and other bone fractures (00:30) What the DEXA bone density scan is and why it matters (3:07) The importance of grip strength (5:02) VO₂ max: what it is, exercises to improve it, and how to get tested (9:10) Longevity-specific testing (24:05) A full lipid panel and everything you need to know about ApoB (28:41) The importance of getting a coronary CT angiogram (40:56) Why getting 10,000 steps a day matters (42:01) Strength training and why tracking your workout progress is essential (57:24) Diet: tracking macros and auditing your calorie intake (1:06:10) GLP-1s: what they are and their impact (1:10:44) Ranking the Mediterranean diet and why calories matter (1:13:31) Sauna, cold plunge, meditation, and mindfulness (1:21:15) Hormone replacement therapy nuances (1:31:36) Top screenings for aging well (1:35:05) Supplements: what’s worth it and what’s not (1:44:08) Where to find Dr. Pardee’s work (1:54:36) Also mentioned in this episode: Plaque Begets Plaque, Not ApoB, JACC Journals  Try This Newsletter Ginny McGonigal  Chris Kresser Article about Misguided Mercury Concerns  For more on Dr. Pardee, follow her on Facebook, Instagram - Modern Med, Instagram, TikTok, Apple Podcasts, LinkedIn, and her Website. This episode is brought to you by Cozy Earth, Branch Basics, and Fatty15. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com/dhru and use code DHRUP. Right now, Branch Basics is offering 15% off the Premium Starter Kit; just go to branchbasics.com and use coupon code DHRU. Make 2025 your cleanest, healthiest year yet with Branch Basics! Fatty15 is offering an additional 15% off its 90-day subscription Starter Kit. Go to fatty15.com/dhru and use code DHRU to replenish your C15 levels for long-term health. Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices
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About Dhru Purohit Show

Hi, I'm Dhru (like Drew), and every week, I interview the top experts in health, medicine, and mindset to provide you with in-depth, step-by-step protocols to take your health to the next level.
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