Samantha Jezak is a biomolecular nutrition researcher completing her PhD at Tufts University, where she studies how diet influences aging at the cellular level. On this episode, we explore the science of longevity through the lens of senescent “zombie” cells, inflammation, and the powerful interaction between nutrition and exercise.
We break down protein hype, keto and carb-loading myths, and why whole foods and micronutrient diversity matter more than extreme diet trends. Samantha also shares her evidence-based perspective on fasting for women, explains the critical role of estrogen in long-term health, and dives into the emerging science of ovarian aging and menopause. Along the way, we discuss how to evaluate nutrition information in a world of social media noise and what the future of “food as medicine” could mean for extending healthspan.
Episode breakdown:
00:00 — Welcome + what Sam studies
00:39 — Senescent cells (hallmark of aging) + nutrition angle
01:55 — Why she chose nutrition + longevity
03:28 — Longevity inputs: genes, exercise, diet, social connection, stress
06:48 — Common misunderstanding: protein hype without training context
09:16 — Keto/low-carb: who it can help + “listen to your body”
11:07 — What a “good diet” means: whole foods + variety
12:36 — Feeling fine vs hidden risk + early markers
14:43 — Nutrient pathways example: niacin → NAD + why restriction can backfire
17:47 — Key micronutrients: vitamin D + magnesium (and creatine)
19:05 — Why supplements aren’t the default: food synergy + absorption
20:33 — Endurance vs strength for longevity
22:39 — High-carb fueling + carb-loading misconceptions
24:23 — Career next steps: postdoc + ovarian aging
26:14 — Fasting for women: autophagy, cortisol, and evidence
30:07 — How to judge nutrition info quality
33:14 — Ovarian aging: follicles, menopause, and the “why” question
35:32 — Estrogen drop: whole-body impacts + HRT reframing
36:59 — Perimenopause: timeline + what women can do now
41:25 — Advice for young scientists
43:12 — The future: AI, robotics, and “food as medicine”
44:39 — Wrap-up
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