Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition
Sarah Ann Macklin

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Top Psychiatrist: Are Antidepressants Making Depression Harder to Escape? | Dr Mark Horowitz
12/08/2026 | 1h 44 mins.⚠️ This episode discusses antidepressants, mental health treatment, withdrawal and sensitive topics around psychiatric medication. Please seek professional guidance before making any changes to your medication.
This week I'm joined by Dr Mark Horowitz, clinical research fellow in psychiatry, co-author of the Maudsley Prescribing Guidelines, and one of the most important voices in the world right now on antidepressants and how to come off them safely.
We explore the science behind antidepressants, what they actually do to the brain, and what nobody told you about coming off them.
Dr Mark Horowitz is a clinical research fellow at University College London and North East London NHS Foundation Trust. He co-authored the Maudsley Deprescribing Guidelines, which have begun to change clinical guidance on antidepressant withdrawal worldwide. His research on tapering and withdrawal has been published in leading medical journals and has directly influenced NHS and international prescribing guidelines. He founded the National Prescribing Support Service and has trained clinicians at Outro Health in America in safer tapering approaches. He has personal experience of antidepressant withdrawal, which led him to dedicate his career to helping others through the same process.
What we explore together:
Why 1 in 6 people in England are on antidepressants — and whether we are overprescribing
What antidepressants actually do to the brain and why the chemical imbalance theory is misleading
Why the clinical trial data on antidepressants is far less impressive than most people realise
The emotional blunting effect — what it is, why it happens and what to do about it
Why 85% of people recover from depression within 12 months with no intervention at all
What withdrawal actually feels like — and why doctors so often get it wrong
How to taper safely and why doing it too fast causes so much unnecessary suffering
What the alternatives to antidepressants are and why they are rarely offered first
Love, Sarah Ann 💛
Learn more about Dr Mark Horowitz and his work:Dr Horowitz on X: https://x.com/markhoroDr Horowitz's website: https://markhorowitz.org/Outro Health's virtual tapering clinic (US): https://www.outro.com/
My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today👉 15% off with code LWBW15 at https://nowatch.com/
PULSETTO: Vagus nerve stimulation for stress, sleep and calm👉 Use code SARAHANN at https://pulsetto.sjv.io/SARAHANN
The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.👉 https://sarahmacklin.substack.com/p/t…
Reset Your HealthIf your body feels off after stress, travel, or burnout — this is where to start.👉 https://sarahmacklin.substack.com/s/r...
👉 Practical beats perfect. Here's a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes
👉 If this resonates, you can join the thousands who read The Compassionate Cure each week.https://sarahmacklin.substack.com/
Let's be friends!📷 Instagram: https://www.instagram.com/sarahannmacklin/
📹 Subscribe: https://youtube.com/@livewellbewellsarah
🐦 Twitter: https://x.com/SarahAnnMacklin
📱 TikTok: https://www.tiktok.com/@livewellbewellpodcast
💌 Newsletter: https://sarahmacklin.substack.com/- This week's Live Well Be Well Moment with Marisa Peer, world-renowned therapist and founder of Rapid Transformational Therapy.
We delve into how Marisa discovered hypnotherapy in West Hollywood, the extraordinary results she saw immediately, and why the subconscious mind responds to hypnosis in a way that no other therapy can replicate.
My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:
NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today. 👉 15% off with code LWBW15 at https://nowatch.com/
PULSETTO: Vagus nerve stimulation for stress, sleep and calm
👉 Use code SARAHANN at https://pulsetto.sjv.io/SARAHANN
More from me: The Great British Veg Out How to support your gut by eating more, not less https://sarahmacklin.substack.com/p/t…
Reset Your Health If your body feels off after stress, travel, or burnout, this is where to start! https://sarahmacklin.substack.com/s/r...
Free 5-recipe PDF for busy weeks https://open.substack.com/pub/sarahma...
Join thousands reading The Compassionate Cure → https://sarahmacklin.substack.com/
Let's be friends!
📷 Instagram https://www.instagram.com/sarahannmacklin
📹 Subscribe https://youtube.com/@livewellbewellsarah?si=UbuuWvMjAcTkELPN
📱 TikTok https://www.tiktok.com/@livewellbewellpodcast?_r=1&_t=ZN-96iOW29jTRm Why You Keep Choosing The Wrong People And How To Break The Cycle | Marisa Peer
07/08/2026 | 11 mins.This week's Live Well Be Well Moment with Marisa Peer, world-renowned therapist and founder of Rapid Transformational Therapy.
We delve into why we keep going back to the wrong relationships, how Marisa met her own husband, and why you were born worthy of love and just need to reactivate what's already there.
My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:
NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today. 👉 15% off with code LWBW15 at https://nowatch.com/
PULSETTO: Vagus nerve stimulation for stress, sleep and calm
👉 Use code SARAHANN at https://pulsetto.sjv.io/SARAHANN
More from me: The Great British Veg Out How to support your gut by eating more, not less https://sarahmacklin.substack.com/p/t…
Reset Your Health If your body feels off after stress, travel, or burnout, this is where to start! https://sarahmacklin.substack.com/s/r...
Free 5-recipe PDF for busy weeks https://open.substack.com/pub/sarahma...
Join thousands reading The Compassionate Cure → https://sarahmacklin.substack.com/
Let's be friends!
📷 Instagram https://www.instagram.com/sarahannmacklin
📹 Subscribe https://youtube.com/@livewellbewellsarah?si=UbuuWvMjAcTkELPN 📱 TikTok https://www.tiktok.com/@livewellbewellpodcast?_r=1&_t=ZN-96iOW29jTRmTop Gut Scientist: Stop Avoiding Gluten, Eat Dairy & Skip Expensive Supplements: Jordan Haworth
05/08/2026 | 1h 30 mins.This week I'm joined by Jordan Haworth, registered dietitian and gut health specialist, and someone who has dedicated his career to understanding one of the most overlooked systems in the human body and how fixing your gut can change everything.
We explore the gut microbiome, what we're getting wrong about healthy eating, and the surprisingly simple changes that can transform your digestion, sleep and wellbeing.
Jordan Haworth is a registered dietitian specialising in gut health and the gut-brain axis. He has worked extensively in both clinical and research settings and is one of the UK's leading voices on the microbiome, IBS, and evidence-based nutrition. Known for cutting through the noise of wellness culture and social media misinformation, Jordan brings clarity, humour and science to one of the most confusing areas of health.
What we explore together:
•Why farting is actually a sign your gut is working and how many times a day is normal
•How trying too hard to fix your gut can actually make it worse
•The eating disorder Jordan developed from trying to eat too healthily — and how he recovered
•Why most of the probiotics on the shelves are what Jordan calls fake probiotics
•The nocebo effect — why your brain can make you physically ill just from believing something
•How you can reverse lactose intolerance by eating more dairy
•Why two kiwis before bed could be the simplest sleep hack you've never tried
•Why squatting on the toilet is better for your bowel movements than sitting
•The link between your oral health and your gut and why mouthwash could be raising your blood pressure
Love, Sarah Ann 💛
My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:
NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today
👉 15% off with code LWBW15 at https://nowatch.com/
PULSETTO: Vagus nerve stimulation for stress, sleep and calm
👉 Use code SARAHANN at https://pulsetto.sjv.io/SARAHANN
The Great British Veg Out
How to support your gut, energy, and hormones by eating more — not less.
👉 https://sarahmacklin.substack.com/p/t…
Reset Your Health
If your body feels off after stress, travel, or burnout — this is where to start.
👉 https://sarahmacklin.substack.com/s/r...
👉 Practical beats perfect. Here's a free 5-recipe PDF I use to support energy and stress during busy weeks.
https://sarahannmacklin.com/5_free_recipes
👉 If this resonates, you can join the thousands who read The Compassionate Cure each week.
https://sarahmacklin.substack.com/
Let's be friends!
📷 Instagram: https://www.instagram.com/sarahannmacklin/
📹 Subscribe: https://youtube.com/@livewellbeViktor Frankl, Meaning Through Suffering And What It Really Means To Live Well | Arthur Brooks
03/08/2026 | 13 mins.This week's Live Well Be Well Moment with Arthur C. Brooks, Harvard professor and New York Times bestselling author.
We delve into meaning, suffering and what Viktor Frankl's story teaches us about finding purpose in the hardest moments of our lives and why the things you don't put on social media might be the most important things of all.
My book 'Healthy Shouldn't Be This Hard': https://www.amazon.co.uk/Healthy-Shouldnt-Be-This-Hard-ebook/dp/B0G1DHNRV5
This episode is sponsored by:
NOWATCH: The compassionate health tracker Connecting body and mind with unique stress recovery insights so you can live fully today. 👉 15% off with code LWBW15 at https://nowatch.com/
PULSETTO: Vagus nerve stimulation for stress, sleep and calm
👉 Use code SARAHANN at https://pulsetto.sjv.io/SARAHANN
More from me: The Great British Veg Out How to support your gut by eating more, not less https://sarahmacklin.substack.com/p/t…
Reset Your Health If your body feels off after stress, travel, or burnout, this is where to start! https://sarahmacklin.substack.com/s/r...
Free 5-recipe PDF for busy weeks https://open.substack.com/pub/sarahma...
Join thousands reading The Compassionate Cure → https://sarahmacklin.substack.com/
Let's be friends!
📷 Instagram https://www.instagram.com/sarahannmacklin
📹 Subscribe https://youtube.com/@livewellbewellsarah?si=UbuuWvMjAcTkELPN
📱 TikTok https://www.tiktok.com/@livewellbewellpodcast?_r=1&_t=ZN-96iOW29jTRm
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About Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition
Health shouldn’t feel this hard.
I’ve lived it, studied it, and now I’m here to help make it make sense.
A smarter, more human way to live well.
Subscribe now, and start living well, for real.
Instagram: @sarahannmacklin
Newsletter: https://substack.com/@sarahannmacklin
Website: sarahannmacklin.com
#LiveWellBeWell
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