Healthspan Over Lifespan: Longevity Lessons for People and Pets with Matt Kaeberlein
In this episode of the Laura Dowling Experience, Matt Kaeberlein, a global leader in ageing science, discusses his mission to help people and animals live longer and healthier lives by modifying the biological mechanisms of ageing. Matt, CEO of Optisan, a healthcare technology company, talks about his transition from academia to entrepreneurship and highlights the importance of lifestyle factors—nutrition, exercise, sleep, and social connection—in maximising health span. The conversation explores emerging approaches to longevity, including hormone therapy, therapeutic plasma exchange, and the use of drugs such as rapamycin and SGLT2 inhibitors. Matt shares personal experiences with ageing-related health strategies and offers valuable insights into the role of love and altruism in achieving a fulfilling life.Timestamps02:48 – Introduction: Meet Matt Kaeberlein, global leader in ageing science03:13 – What does Matt Kaeberlein do? Biological mechanisms of ageing04:40 – The concept of health span vs. lifespan06:55 – Four pillars of health span: Eat, Move, Sleep, Connect09:04 – The importance of human and animal connection11:06 – Beyond lifestyle: Hormones and health span16:06 – Menopause, HRT, and women’s health24:55 – Testosterone therapy for men: Risks and benefits31:35 – Alcohol, lifestyle, and longevity34:34 – Environmental exposures: Heavy metals, microplastics, and health39:44 – Therapeutic plasma exchange and ageing research47:09 – Rapamycin: The science, trials, and potential for longevity59:46 – Diet, fasting, and inflammation: What Matt Kaeberlein eats1:07:32 – Continuous glucose monitoring and behaviour change1:14:07 – SGLT2 inhibitors and other promising drugs1:19:07 – Final advice: Choose love, not fear; the meaning of lifeThanks for listening! You can watch the full episode on YouTube here. Don’t forget to follow The Laura Dowling Experience podcast on Instagram @lauradowlingexperience for updates and more information. You can also follow our host, Laura Dowling, @fabulouspharmacist for more insights and tips. If you enjoyed this episode, please subscribe and leave a review—it really helps us out! Stay tuned for more great conversations. Hosted on Acast. See acast.com/privacy for more information.